Prosthetics and Dental Materials, Faculty of Dental Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania.
Stomestet Stomatology Clinic, Calea Manastur 68A Street, 400658 Cluj-Napoca, Romania;
Cells. 2019 Jan 8;8(1):29. doi: 10.3390/cells8010029.
Tissue engineering has gained much momentum since the implementation of stem cell isolation and manipulation for regenerative purposes. Despite significant technical improvements, researchers still have to decide which strategy (which type of stem cell) is the most suitable for their specific purpose. Therefore, this short review discusses the advantages and disadvantages of the three main categories of stem cells: embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the context of bone regeneration for dentistry-associated conditions. Importantly, when deciding upon the right strategy, the selection needs to be made in concordance with the morbidity and the life-threatening level of the condition in discussion. Therefore, even when a specific type of stem cell holds several advantages over others, their availability, invasiveness of the collection method and ethical standards become deciding parameters.
自干细胞分离和操纵技术应用于再生医学以来，组织工程取得了很大的进展。尽管技术有了很大的改进，但研究人员仍然需要决定哪种策略（哪种类型的干细胞）最适合他们的特定目的。因此，本文简要讨论了胚胎干细胞、间充质干细胞和诱导多能干细胞在牙科相关疾病骨再生方面的优缺点。重要的是，在决定正确的策略时，需要根据所讨论疾病的发病率和危及生命程度来选择。因此，即使某种类型的干细胞比其他类型具有更多的优势，其可用性、采集方法的侵入性和伦理标准也成为决定因素。
