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髋关节骨关节炎的关节内透明质酸注射。

Intra-articular hyaluronic acid injections for hip osteoarthritis.

机构信息

Rehabilitation Unit, Paolo Giaccone Hospital, Palermo, Italy.

Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli, Bologna, Italy.

出版信息

J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1303-1309.

Abstract

Although viscosupplementation has been used in the past few years both for knee and hip osteoarthritis (OA), the number of intra-articular injections and the interval between doses still remains an undetermined subject. The aim of this open retrospective study was to evaluate the clinical and functional outcome in patients with mild-moderate hip OA treated with a course of 1, 2 or 3 Hyaluronic Acid (HA) intra-articular injections. Ninety-six patients were included: 19 patients received only one injection, 24 received two injections, and 44 received three injections. Age, sex, VAS for pain and WOMAC score before each intra-articular injection, number of intra-articular injections, reasons for interrupting the treatment, adverse events, time between HA injections, and number of patients who had a total hip replacement were retrieved from the medical records of each patient. VAS and WOMAC scores were obtained from all patients also at a mean follow-up of 7 months after the last hip injection. All patients who received 1, 2 or 3 hip injections improved in VAS and WOMAC score. Three intra-articular injections provided a better outcome in terms of pain reduction compared to 1 or 2 injections. Intrarticular injections for mild-moderate hip OA were demonstrated to be effective in reducing pain and improving function. A full course of three injections provided the best result in pain control.

摘要

虽然在过去几年中,黏弹性补充剂已被用于膝关节和髋关节骨关节炎(OA)的治疗,但关节内注射的次数和剂量间隔仍未确定。本开放性回顾性研究旨在评估接受 1、2 或 3 次透明质酸(HA)关节内注射治疗的轻度至中度髋关节 OA 患者的临床和功能结局。共纳入 96 例患者:19 例仅接受 1 次注射,24 例接受 2 次注射,44 例接受 3 次注射。从每位患者的病历中检索了年龄、性别、每次关节内注射前的疼痛视觉模拟评分(VAS)和 WOMAC 评分、关节内注射次数、中断治疗的原因、不良反应、HA 注射间隔时间以及接受全髋关节置换术的患者人数。所有患者还在最后一次髋关节注射后 7 个月的平均随访时获得了 VAS 和 WOMAC 评分。所有接受 1、2 或 3 次髋关节注射的患者在 VAS 和 WOMAC 评分方面均有改善。与 1 次或 2 次注射相比,3 次关节内注射在减轻疼痛方面效果更好。关节内注射治疗轻度至中度髋关节 OA 可有效减轻疼痛并改善功能。全程 3 次注射在疼痛控制方面效果最佳。

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