Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, Pontedera (Pisa) 56025, Italy.
Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale Rinaldo Piaggio 34, Pontedera (Pisa) 56025, Italy.
Nanomedicine (Lond). 2018 Nov;13(22):2821-2833. doi: 10.2217/nnm-2018-0316. Epub 2018 Oct 18.
Oxidative stress (OS) is strictly associated with senescence/pathogenesis of biological systems. As putative countermeasure to environmental OS, cerium oxide nanoparticles (nanoceria [NC]) were administered to muscle cells on ground and aboard the International Space Station.
MATERIALS & METHODS: Transcriptional analyses were conducted through microarray technology and hierarchical clustering. Venn diagram and gene ontology analyses were also performed on selected gene lists.
Adaptive responses to both NC administration and to permanence in real microgravity conditions occurred. Enrichment in the biological processes related to aging, body fat development and mesodermal tissue proliferation for NC-treated samples were found.
Nanotechnology antioxidants promise applications to pathological conditions governed by OS on Earth and in life-hostile environments (low Earth orbit and deep space).
氧化应激（OS）与生物系统的衰老/发病机制密切相关。作为对环境 OS 的潜在对策，氧化铈纳米粒子（纳米铈 [NC]）被施用于地面和国际空间站上的肌肉细胞。
通过微阵列技术和层次聚类进行转录分析。还对选定的基因列表进行了 Venn 图和基因本体分析。
NC 给药和在真实微重力条件下持续存在都发生了适应性反应。在 NC 处理的样本中发现了与衰老、体脂肪发育和中胚层组织增殖相关的生物学过程的富集。
纳米技术抗氧化剂有望应用于由 OS 引起的病理状况，无论是在地球上还是在生命恶劣的环境（低地球轨道和深空）中。
