Madkhali Ahmad Abdullah, Shin Sang-Hyun, Song Ki Byung, Lee Jae Hoon, Hwang Dae Wook, Park Kwang Min, Lee Young Joo, Kim Song Cheol
Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hepato-Biliary and Pancreatic Surgery unit, Department of Surgery, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Medicine (Baltimore). 2018 Oct;97(42):e12653. doi: 10.1097/MD.0000000000012653.
The aim of the present study was to evaluate the short- and long-term outcomes of secondary metastasis to the pancreas in terms of overall survival (OS) and disease-free survival (DFS) after pancreatectomy.This retrospective study included 29 patients who underwent pancreatectomy for secondary metastasis to the pancreas between December 1995 and August 2016.The study group was divided into renal cell carcinoma (RCC) (17 patients) and non-RCC (12 patients). The non-RCC group had 5 cases of colorectal cancer and 7 of another primary origin. The OS for the whole cohort was 86.2% at 1 year, 63.2% at 3 years, and 46.7% at 5 years. There was no significant difference between the 2 groups at 1, 3, and 5 years survival and OS. In subgroup analysis of patients who underwent curative resection, there was no significant difference in OS between the 2 groups at 1, 3, and 5 years. However, there was a significant difference in recurrence rate at 3 years (P = .035). Pathologic analysis showed that the non-RCC group had significantly more positive lymph node metastasis than the RCC group (P = .002).Pancreatectomy for secondary metastasis has promising short- and long-term outcomes in terms of OS and DFS.
本研究的目的是评估胰腺切除术后胰腺继发转移在总生存期（OS）和无病生存期（DFS）方面的短期和长期预后。这项回顾性研究纳入了1995年12月至2016年8月期间因胰腺继发转移而接受胰腺切除术的29例患者。研究组分为肾细胞癌（RCC）组（17例患者）和非RCC组（12例患者）。非RCC组有5例结直肠癌和7例其他原发肿瘤。整个队列的1年总生存率为86.2%，3年为63.2%，5年为46.7%。两组在1年、3年和5年生存率及总生存期方面无显著差异。在接受根治性切除的患者亚组分析中，两组在1年、3年和5年的总生存期无显著差异。然而，3年复发率存在显著差异（P = 0.035）。病理分析显示，非RCC组的阳性淋巴结转移明显多于RCC组（P = 0.002）。就总生存期和无病生存期而言，胰腺继发转移的胰腺切除术具有良好的短期和长期预后。
