Department of Nuclear Medicine , Tianjin Medical University General Hospital , Tianjin 300052 , P. R. China.
School of Medical Imaging , Tianjin Medical University , Tianjin 300203 , P. R. China.
ACS Appl Mater Interfaces. 2018 Nov 14;10(45):38729-38738. doi: 10.1021/acsami.8b12394. Epub 2018 Oct 30.
Metal-organic frameworks (MOFs) have been applied in chemotherapeutic drug loading for cancer treatment, but challenging for cases with large and malignant lesions. To overcome these difficulties, combinational therapies of chemotherapy and photothermal therapy (PTT) with potentially high selectivity and slight aggressiveness have drawn tremendous attention to treat various tumors. However, current MOF-based nanohybrids with photothermal agents involve tedious synthesis processes and heterogeneous structures. Herein, we employ MIL-53 as a microreactor to grow polypyrrole (PPy) nanoparticles in situ for the fabrication of PPy@MIL-53 nanocomposites. Fe in MIL-53, as an intrinsic oxidizing agent, can oxidize the pyrrole monomer to generate PPy nanoparticles. The prepared PPy@MIL-53 nanocomposites integrate the intrinsic advantages of MOFs with high drug loading ability and magnetic resonance imaging (MRI) capacity, and PPy nanoparticles with outstanding PTT ability and excellent biocompatibility. The versatile PPy@MIL-53 nanocomposites with multiple functions displayed in vitro and in vivo synergism of photothermal-chemotherapy for cancer, potentially MRI-guided. The proposed MOF microreactor-based synthesis strategy shows a promising prospect in the fabrication of diverse multifunctional nanohybrids for tumor theranostics in vivo.
金属-有机骨架（MOFs）已被应用于化疗药物负载以治疗癌症，但对于大而恶性的病变情况仍然具有挑战性。为了克服这些困难，化疗和光热治疗（PTT）的联合治疗具有高选择性和轻微侵袭性，引起了人们极大的关注，可用于治疗各种肿瘤。然而，目前基于 MOF 的具有光热剂的纳米杂化物涉及繁琐的合成过程和异质结构。在此，我们采用 MIL-53 作为微反应器，原位生长聚吡咯（PPy）纳米颗粒，制备 PPy@MIL-53 纳米复合材料。MIL-53 中的 Fe 作为内在的氧化剂，可以将吡咯单体氧化生成 PPy 纳米颗粒。所制备的 PPy@MIL-53 纳米复合材料集成了 MOFs 的固有优势，具有高载药能力和磁共振成像（MRI）能力，以及 PPy 纳米颗粒具有出色的 PTT 能力和优异的生物相容性。多功能 PPy@MIL-53 纳米复合材料在体外和体内均表现出光热-化疗的协同作用，具有潜在的 MRI 引导作用。基于 MOF 微反应器的合成策略在体内肿瘤治疗的多功能纳米杂化物的制备方面具有广阔的前景。
