University of Chinese Academy of Sciences , Beijing 100049 , China.
ACS Appl Mater Interfaces. 2018 Dec 5;10(48):41035-41045. doi: 10.1021/acsami.8b13492. Epub 2018 Nov 26.
Imaging-guided therapy has considerable potential in tumor treatment. Different treatments have been integrated to realize combinational tumor therapy with improved therapeutic efficiency. Herein, the conventional metal-organic framework (MOF) MIL-100 is utilized to load curcumin with excellent encapsulation capacity. Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). The HA-PDA coating not only improves the dispersibility and stability of NPs but also introduces a tumor-targeting ability to this nanosystem. A two-stage augmented photothermal conversion capability is introduced to this nanosystem by encapsulating curcumin in MIL-100 pores and then coating HA-PDA on the surface, which confer the MCH NPs with strong photothermal conversional efficiency. After being intravenously injected into xenograft HeLa tumor-bearing mice, MCH NPs prefer to accumulate at the tumor site and achieve photoacoustic imaging-guided chemo-/photothermal combinational tumor therapy, generating nearly complete tumor ablation. Engineering MOFs is an efficient platform for imaging-guided combinational tumor therapy, as confirmed by in vitro and in vivo evaluations.
影像引导治疗在肿瘤治疗中具有很大的潜力。不同的治疗方法已经被整合在一起，以实现联合肿瘤治疗，提高治疗效率。在此，我们利用传统的金属有机骨架（MOF）MIL-100 来负载姜黄素，以获得优异的包封能力。然后，我们在 MIL-100 表面包覆聚多巴胺修饰的透明质酸（HA-PDA），构建工程 MOF 纳米颗粒（MCH NPs）。HA-PDA 涂层不仅提高了 NPs 的分散性和稳定性，还为这个纳米系统引入了肿瘤靶向能力。通过将姜黄素封装在 MIL-100 孔中，然后在表面包覆 HA-PDA，为这个纳米系统引入了两阶段增强的光热转换能力，赋予了 MCH NPs 很强的光热转换效率。将 MCH NPs 静脉注射到荷瘤 HeLa 移植瘤小鼠体内后，MCH NPs 优先聚集在肿瘤部位，实现了光声成像引导的化疗/光热联合肿瘤治疗，几乎完全消融了肿瘤。通过体外和体内评估证实，工程 MOFs 是一种用于影像引导联合肿瘤治疗的有效平台。
