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单侧眼球摘除后大鼠皮质下视觉中枢细胞色素氧化酶活性的变化。

Changes of cytochrome oxidase activity in the rat subcortical visual centers after unilateral eye enucleation.

作者信息

Sukekawa K

出版信息

Neurosci Lett. 1987 Mar 31;75(2):127-32. doi: 10.1016/0304-3940(87)90285-0.

DOI:10.1016/0304-3940(87)90285-0
PMID:3033559
Abstract

Histochemical densitometric measurements of cytochrome oxidase (CO) activity in the dorsal and ventral lateral geniculate nuclei (LGNd and LGNv) and the superficial gray stratum of the superior colliculus (SC) were done between 2 and 12 weeks after unilateral enucleation in the adult albino rat. This deafferentation resulted in a transient, slight but statistically significant decrease in CO activity in the contralateral LGNd and LGNv. Whereas in the contralateral SC, a marked reduction in CO activity was observed, and this persisted over the postoperative periods studied. The regional difference in the recovery pattern of CO activity were discussed from the aspect of synaptic reorganization.

摘要

在成年白化大鼠单侧眼球摘除术后2至12周期间,对背侧和腹侧外侧膝状核(LGNd和LGNv)以及上丘浅层灰质(SC)中的细胞色素氧化酶(CO)活性进行了组织化学密度测量。这种传入神经阻滞导致对侧LGNd和LGNv中的CO活性出现短暂、轻微但具有统计学意义的下降。而在对侧SC中,观察到CO活性显著降低,并且在研究的术后期间持续存在。从突触重组的角度讨论了CO活性恢复模式的区域差异。

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