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服用退烧药、麦角酸二乙胺、Δ⁹-四氢大麻酚及相关药物后体温的变化:II

Changes in body temperature after administration of antipyretics, LSD, delta 9-THC and related agents: II.

作者信息

Clark W G

出版信息

Neurosci Biobehav Rev. 1987 Spring;11(1):35-96. doi: 10.1016/s0149-7634(87)80003-9.

DOI:10.1016/s0149-7634(87)80003-9
PMID:3033566
Abstract

Antipyretics, in particular acetaminophen, aspirin and ibuprofen, constitute the single most important class of drugs used therapeutically for an effect on body temperature. Hallucinogens exert prominent actions on the central nervous system, and it is not surprising that, like so many other centrally-acting agents, they too often affect temperature. This compilation primarily covers the considerable amount of data published from 1981 through 1985 on the interactions of these drugs and thermoregulation, but data from many earlier papers not included in a previous compilation are also tabulated. The effects of agents not classically considered as antipyretics on temperatures of febrile subjects are also covered. The information listed includes the species used, the route of administration and dose of drug, the environmental temperature at which experiments were performed, the number of tests, the direction and magnitude of change in body temperature and remarks on special conditions, such as age or brain lesions. Also indicated is the influence of other drugs, such as antagonists, on the response to the primary agent.

摘要

退热药,特别是对乙酰氨基酚、阿司匹林和布洛芬,是治疗上用于影响体温的最重要的一类药物。致幻剂对中枢神经系统有显著作用,与许多其他作用于中枢的药物一样,它们经常影响体温也就不足为奇了。本汇编主要涵盖了1981年至1985年发表的关于这些药物与体温调节相互作用的大量数据,但许多早期论文中未包含在先前汇编中的数据也被制成表格列出。还涵盖了通常不被视为退热药的药物对发热受试者体温的影响。列出的信息包括所用物种、给药途径和药物剂量、进行实验时的环境温度、测试次数、体温变化的方向和幅度以及关于特殊情况(如年龄或脑部病变)的说明。还指出了其他药物(如拮抗剂)对主要药物反应的影响。

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