Chen D A, Mandell-Brown M, Moore S F, Johnson J T
Otolaryngol Head Neck Surg. 1986 Jul;95(1):99-103. doi: 10.1177/019459988609500119.
Mixed squamous and oat cell carcinomas (composite neoplasms) of the larynx behave aggressively with a propensity toward early dissemination. Diagnosis may not be made until definitive surgery is performed. The extent of surgery must be determined by the size and site of the primary neoplasm and the physiologic status of the patient. In our experience, surgery has adequately controlled the primary disease. A metastatic work-up is essential. Entry into a comprehensive program employing adjunctive radiotherapy and chemotherapy are strongly recommended. Theories concerning histogenesis remain controversial and include two separate colliding tumors, differentiation from a single cell line, or divergent differentiation of a single cell line.
喉鳞状细胞癌和燕麦细胞癌混合性癌（复合性肿瘤）侵袭性强，易于早期播散。直到进行确定性手术时才能确诊。手术范围必须根据原发肿瘤的大小和部位以及患者的生理状况来确定。根据我们的经验，手术已充分控制了原发疾病。进行转移灶检查至关重要。强烈建议加入采用辅助放疗和化疗的综合治疗方案。关于组织发生的理论仍存在争议，包括两种独立的碰撞肿瘤、源自单一细胞系的分化或单一细胞系的异向分化。
