炎症细胞因子对骨/软骨修复的影响。

Effects of inflammatory cytokines on bone/cartilage repair.

作者信息

Zhang Tingshuai, Yao Yongchang

机构信息

Department of Joint Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Guangdong Key Laboratory of Orthopaedic Technology And Implant Materials, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

出版信息

J Cell Biochem. 2019 May;120(5):6841-6850. doi: 10.1002/jcb.27953. Epub 2018 Oct 18.

DOI:10.1002/jcb.27953

PMID:30335899

Abstract

Many inflammatory factors can affect cell behaviors and work as a form of inter-regulatory networks through the inflammatory pathway. Inflammatory cytokines are critical for triggering bone regeneration after fracture or bone injury. Also, inflammatory cytokines play an important role in cartilage repair. The synergistic or antagonistic effects of both proinflammatory and anti-inflammatory cytokines have a great influence on fracture healing. This review discusses key inflammatory cytokines and signaling pathways involved in bone or cartilage repair.

摘要

许多炎症因子可影响细胞行为，并通过炎症途径形成一种相互调节网络的形式。炎症细胞因子对于骨折或骨损伤后触发骨再生至关重要。此外，炎症细胞因子在软骨修复中也发挥着重要作用。促炎细胞因子和抗炎细胞因子的协同或拮抗作用对骨折愈合有很大影响。本综述讨论了参与骨或软骨修复的关键炎症细胞因子和信号通路。