Argiolas A, Melis M R, Mauri A, Gessa G L
Department of Neurosciences, University of Cagliari, Italy.
Psychopharmacology (Berl). 1989;97(3):383-7. doi: 10.1007/BF00439455.
Penile erection and yawning induced by the intracerebroventricular (ICV) injection of oxytocin (10-1000 ng) was studied in hypophysectomized rats and in rats neonatally treated with monosodium glutamate (MSG), a treatment that depletes hypothalamic opiomelanocorticotropin-derived peptides without altering their pituitary and circulating concentration. Oxytocin effect was strongly reduced by hypophysectomy, but not by neonatal MSG. Testosterone replacement (50 micrograms/kg/day for 23 days) partially reversed the effect of hypophysectomy on penile erection, but not on yawning. The present results suggest that oxytocin does not induce penile erection and yawning by releasing an ACTH-derived peptide from hypothalamic opiomelanotropinergic neurons, and that the pituitary gland exerts a permissive role on the expression of the above behavioural responses induced by oxytocin.
在垂体切除的大鼠以及新生期用谷氨酸单钠（MSG）处理的大鼠中研究了脑室内（ICV）注射催产素（10 - 1000 ng）诱导的阴茎勃起和打哈欠情况。MSG处理可耗尽下丘脑阿片促黑素细胞皮质素衍生肽，但不改变其垂体和循环浓度。垂体切除可强烈降低催产素的作用，但新生期用MSG处理则不会。睾酮替代（50微克/千克/天，持续23天）部分逆转了垂体切除对阴茎勃起的影响，但对打哈欠没有影响。目前的结果表明，催产素并非通过从下丘脑阿片促黑素能神经元释放促肾上腺皮质激素衍生肽来诱导阴茎勃起和打哈欠，并且垂体对催产素诱导的上述行为反应的表达发挥允许作用。
