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American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation.美国胃肠病学会关于阿片类药物所致便秘药物治疗的指南
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Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis.与癌症患者中纳洛酮治疗阿片类药物引起的便秘无应答相关的因素：亚组分析。
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TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice.TY-S01通过调节小鼠肠道微生物群及其代谢产物预防洛哌丁胺诱导的便秘。
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Effects of Maren Pills on the Intestinal Microflora and Short-Chain Fatty Acid Profile in Drug-Induced Slow Transit Constipation Model Rats.麻仁丸对药物诱导的慢传输型便秘模型大鼠肠道菌群及短链脂肪酸谱的影响
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本文引用的文献

1
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis.阿片类药物引起的便秘的药物治疗疗效：系统评价和网络荟萃分析。
Gut. 2019 Mar;68(3):434-444. doi: 10.1136/gutjnl-2018-316001. Epub 2018 May 5.
2
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study.长期使用纳洛美丁治疗慢性非癌痛患者阿片类药物引起的便秘：一项随机、双盲、安慰剂对照的 3 期研究。
Pain. 2018 May;159(5):987-994. doi: 10.1097/j.pain.0000000000001174.
3
Efficacy of Treatments for Opioid-Induced Constipation: Systematic Review and Meta-analysis.阿片类药物引起的便秘的治疗效果：系统评价和荟萃分析。
Clin Gastroenterol Hepatol. 2018 Oct;16(10):1569-1584.e2. doi: 10.1016/j.cgh.2018.01.021. Epub 2018 Jan 31.
4
Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Constipation: Phase 3 Study Results and Pooled Analysis of the Effect of Concomitant Methadone Use on Clinical Outcomes.鲁比前列酮治疗阿片类药物诱导性便秘的疗效和安全性：3 期研究结果及合并使用美沙酮对临床结局影响的汇总分析。
Pain Med. 2018 Jun 1;19(6):1184-1194. doi: 10.1093/pm/pnx156.
5
Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer.纳洛美丁治疗阿片类药物引起的便秘和癌症患者的随机 III 期和扩展研究。
J Clin Oncol. 2017 Dec 1;35(34):3859-3866. doi: 10.1200/JCO.2017.73.0853. Epub 2017 Oct 2.
6
Prescription Opioid Use, Misuse, and Use Disorders in U.S. Adults: 2015 National Survey on Drug Use and Health.美国成年人的处方阿片类药物使用、滥用和使用障碍：2015 年全国毒品使用与健康调查。
Ann Intern Med. 2017 Sep 5;167(5):293-301. doi: 10.7326/M17-0865. Epub 2017 Aug 1.
7
Comparing Healthcare Utilization and Costs Among Medicaid-Insured Patients with Chronic Noncancer Pain with and without Opioid-Induced Constipation: A Retrospective Analysis.比较有无阿片类药物引起便秘的医疗补助保险慢性非癌性疼痛患者的医疗服务利用情况和费用：一项回顾性分析。
Am Health Drug Benefits. 2017 Apr;10(2):79-86.
8
Prevalence and clinical features of opioid-induced constipation in the general population: A French study of 15,000 individuals.普通人群中阿片类药物所致便秘的患病率及临床特征：一项针对15000人的法国研究
United European Gastroenterol J. 2017 Jun;5(4):588-600. doi: 10.1177/2050640616659967. Epub 2016 Jul 7.
9
Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials.纳洛美丁与安慰剂治疗阿片类药物引起的便秘（COMPOSE-1 和 COMPOSE-2）：两项多中心、3 期、双盲、随机、平行组试验。
Lancet Gastroenterol Hepatol. 2017 Aug;2(8):555-564. doi: 10.1016/S2468-1253(17)30105-X. Epub 2017 May 30.
10
The GRADE Working Group clarifies the construct of certainty of evidence.GRADE工作组对证据确定性的概念进行了澄清。
J Clin Epidemiol. 2017 Jul;87:4-13. doi: 10.1016/j.jclinepi.2017.05.006. Epub 2017 May 18.

American Gastroenterological Association Institute Technical Review on the Medical Management of Opioid-Induced Constipation.

作者信息

Hanson Brian, Siddique Shazia Mehmood, Scarlett Yolanda, Sultan Shahnaz

机构信息

Division of Gastroenterology and Hepatology, University of Minnesota and Minneapolis Veterans Affairs Healthcare System, Minneapolis, Minnesota.

Division of Gastroenterology and Liver Disease, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

Gastroenterology. 2019 Jan;156(1):229-253.e5. doi: 10.1053/j.gastro.2018.08.018. Epub 2018 Oct 16.

DOI:10.1053/j.gastro.2018.08.018
PMID:30337104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6685294/
Abstract
摘要