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TY-S01通过调节小鼠肠道微生物群及其代谢产物预防洛哌丁胺诱导的便秘。

TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice.

作者信息

Tang Tian, Wang Jing, Jiang Yuanyuan, Zhu Xu, Zhang Zhen, Wang Yuying, Shu Xi, Deng Yadan, Zhang Feng

机构信息

Chongqing Tianyou Dairy Co., Ltd., Chongqing, China.

出版信息

Front Nutr. 2022 Jun 29;9:890314. doi: 10.3389/fnut.2022.890314. eCollection 2022.

DOI:10.3389/fnut.2022.890314
PMID:35845767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277448/
Abstract

Probiotics have received widespread attention as a healthy ingredient. The preventive effect of TY-S01 on loperamide-induced constipation in mice was investigated in this study. TY-S01 accelerated the peristalsis of intestine, maintained the humidity of faeces, and prevented the destruction of gut barrier. TY-S01 also maintained the 5-HT, MTL and SP at normal levels in constipated mice. Simultaneously, TY-S01 up-regulated the mRNA expressions of 5-HTR, SERT, and MUC-2, while down-regulated the mRNA expressions of pro-inflammatory genes remarkably. The levels of short-chain fatty acids in the feces of constipated mice were also increased because of the intervention with TY-S01. Moreover, TY-S01 prevented gut microbiological dysbiosis in constipated mice. Spearman's correlation analysis revealed that there was an obvious association between metabolic biomarkers and gut microbiota. In summary, TY-S01 regulated gut microbiota and the production of intestinal metabolites to prevent loperamide-induced constipation.

摘要

益生菌作为一种健康成分受到了广泛关注。本研究考察了TY-S01对洛哌丁胺诱导的小鼠便秘的预防作用。TY-S01可加速肠道蠕动，保持粪便湿度，防止肠道屏障破坏。TY-S01还可使便秘小鼠的5-羟色胺、胃动素和P物质维持在正常水平。同时，TY-S01上调5-羟色胺受体、5-羟色胺转运体和黏蛋白-2的mRNA表达，同时显著下调促炎基因的mRNA表达。由于TY-S01的干预，便秘小鼠粪便中的短链脂肪酸水平也有所增加。此外，TY-S01可防止便秘小鼠肠道微生物群失调。Spearman相关性分析显示，代谢生物标志物与肠道微生物群之间存在明显关联。综上所述，TY-S01通过调节肠道微生物群和肠道代谢产物的产生来预防洛哌丁胺诱导的便秘。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b25/9277448/5ae4728f866f/fnut-09-890314-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b25/9277448/c19540c7ad10/fnut-09-890314-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b25/9277448/3e43c0c7f29b/fnut-09-890314-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b25/9277448/5ae4728f866f/fnut-09-890314-g007.jpg

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