Kamali Alireza, Ahmadi Lida, Shokrpour Maryam, Pazuki Shirin
Department of Anesthesiology, Arak University of Medical Sciences, Arak, Iran.
Department of Gynecology, Arak University of Medical Sciences, Arak, Iran.
Open Access Maced J Med Sci. 2018 Sep 24;6(9):1659-1663. doi: 10.3889/oamjms.2018.366. eCollection 2018 Sep 25.
This study was aimed to compare the effects of ondansetron, haloperidol, and dexmedetomidine for reducing postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.
This randomised clinical trial study was performed on p.patients who were candidates for abdominal hysterectomy referring to Taleghani hospital in Arak. In this study, 114 patients with abdominal hysterectomy were randomly assigned to three groups (ondansetron, haloperidol, and dexmedetomidine) using the cubull randomisation method.
The results revealed a significant difference between the three groups of ondansetron, haloperidol and dexmedetomidine in terms of scorpion vomiting in recovery, 2 and 4 hours after surgery, and vomiting score was significantly lower in the ondansetron group compared with the other two groups (P = 0.04; P = 0.02; P = 0.001). There was a significant difference between the three groups of e ondansetron, haloperidol and dexmedetomidine regarding the mean dose of metoclopramide in mg for 24 hours after surgery. Therefore, the dosage of dexmedetomidine in the ondansetron group was less than the other two groups (P = 0.001).
these three drugs are effective in reducing PONV in patients undergoing a hysterectomy. However, the effect of ondansetron was found to be more than the other two drugs in reducing PONV.
本研究旨在比较昂丹司琼、氟哌啶醇和右美托咪定对减少腹腔镜胆囊切除术后恶心呕吐（PONV）的效果。
本随机临床试验对前往阿拉克塔莱哈尼医院接受腹部子宫切除术的患者进行。在本研究中，114例接受腹部子宫切除术的患者采用随机数字表法随机分为三组（昂丹司琼、氟哌啶醇和右美托咪定）。
结果显示，昂丹司琼、氟哌啶醇和右美托咪定三组在术后恢复、术后2小时和4小时的恶心呕吐方面存在显著差异，与其他两组相比，昂丹司琼组的呕吐评分显著更低（P = 0.04；P = 0.02；P = 0.001）。昂丹司琼、氟哌啶醇和右美托咪定三组在术后24小时甲氧氯普胺的平均剂量（毫克）方面存在显著差异。因此，昂丹司琼组的右美托咪定剂量低于其他两组（P = 0.001）。
这三种药物对减少接受子宫切除术患者的PONV有效。然而，发现昂丹司琼在减少PONV方面的效果优于其他两种药物。
