定量二次谐波产生显微镜用于甲状腺肿瘤中包膜胶原蛋白的结构表征。
Quantitative second harmonic generation microscopy for the structural characterization of capsular collagen in thyroid neoplasms.
作者信息
Hristu Radu, Eftimie Lucian G, Stanciu Stefan G, Tranca Denis E, Paun Bogdan, Sajin Maria, Stanciu George A
机构信息
Center for Microcopy-Microanalysis and Information Processing, University Politehnica of Bucharest, Bucharest, Romania.
Central University Emergency Military Hospital, Pathology Department, 134 Calea Plevnei, 010825 Bucharest, Romania.
出版信息
Biomed Opt Express. 2018 Jul 30;9(8):3923-3936. doi: 10.1364/BOE.9.003923. eCollection 2018 Aug 1.
Abstract
Quantitative second harmonic generation microscopy was used to investigate collagen organization in the fibrillar capsules of human benign and malignant thyroid nodules. We demonstrate that the combination of texture analysis and second harmonic generation images of collagen can be used to differentiate between capsules surrounding the thyroid follicular adenoma and papillary carcinoma nodules. Our findings indicate that second harmonic generation microscopy can provide quantitative information about the collagenous capsule surrounding both the thyroid and thyroid nodules, which may complement traditional histopathological examination.
摘要
定量二次谐波产生显微镜术被用于研究人类良性和恶性甲状腺结节纤维囊中的胶原蛋白组织。我们证明，胶原蛋白的纹理分析和二次谐波产生图像相结合可用于区分甲状腺滤泡性腺瘤和乳头状癌结节周围的囊。我们的研究结果表明，二次谐波产生显微镜术可以提供有关甲状腺及其结节周围胶原囊的定量信息，这可能补充传统的组织病理学检查。
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