Tanaka Y, Kanaya I, Takahashi Y, Shinose M, Tanaka H, Omura S
Research Center for Biological Function, Kitasato Institute, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 1993 Aug;46(8):1208-13. doi: 10.7164/antibiotics.46.1208.
A new inhibitor of cellulose biosynthesis named phthoxazolin A was discovered as a metabolite of Streptomyces sp. OM-5714. A newly established screening method, which utilized a cellulose-containing fungus, Phytophthora sp. as a test organism, was successfully employed for discovery of the compound. Phthoxazolin A, C16H22N2O3 (MW of 290), is a lipophilic triene compound with an oxazole moiety. It has moderate antifungal activity against Phytophthora spp. only and has potent herbicidal activity. Phosphate-limited fermentation conditions favored production of the active compound.
一种名为邻苯恶唑啉A的新型纤维素生物合成抑制剂，作为链霉菌属OM-5714的代谢产物被发现。一种新建立的筛选方法，利用含纤维素的真菌疫霉属作为测试生物，成功用于该化合物的发现。邻苯恶唑啉A，C16H22N2O3（分子量290），是一种带有恶唑部分的亲脂性三烯化合物。它仅对疫霉属具有中等抗真菌活性，并具有强效除草活性。磷酸盐限制的发酵条件有利于活性化合物的产生。
