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由……产生的恶唑霉素及其细胞毒性活性。 （原句表述不完整，推测是这样翻译，完整准确的句子应该是“由……产生的恶唑霉素及其细胞毒性活性的研究”之类，这里根据现有内容尽量贴近原意翻译）

Oxazolomycins produced by and their cytotoxic activity.

作者信息

Mu Yu, Jiang Yi, Qu Xiaodan, Liu Bo, Tan Junfeng, Li Guiding, Jiang Mingguo, Li Liya, Han Li, Huang Xueshi

机构信息

Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University Shenyang 110819 China

Yunnan Institute of Microbiology, Yunnan University Kunming 650091 China

出版信息

RSC Adv. 2021 Oct 28;11(55):35011-35019. doi: 10.1039/d1ra06182h. eCollection 2021 Oct 25.

DOI:10.1039/d1ra06182h
PMID:35494745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9042891/
Abstract

Six oxazolomycins (1-6) were isolated from the fermentation broth of a soil-borne bacterial strain, . The structures of the new compounds, oxazolomycins D-F (1-3) and glaucumycins A, B (6a/6b), were elucidated by detailed spectroscopic data analysis. Oxazolomycins 1, 2, 4, and 5 demonstrated weak or modest cytotoxic activities against four human cancer cell lines, with IC values ranging from 10.6 ± 1.7 to 89.5 ± 6.6 μM (or >100 μM). Further study showed that 4 caused S phase cell cycle arrest in SMMC7721 cells through down-regulating the protein expression of cyclin A2, CDK2. Meanwhile, 4 induced apoptosis in SMMC7721 cells through down-regulating the protein levels of Bcl-2, up-regulating the levels of Bax, and activating the cleavage of caspase-3.

摘要

从一株土壤细菌菌株的发酵液中分离出了六种恶唑霉素（1-6）。通过详细的光谱数据分析阐明了新化合物恶唑霉素D-F（1-3）和青霉菌素A、B（6a/6b）的结构。恶唑霉素1、2、4和5对四种人类癌细胞系表现出微弱或中等的细胞毒性活性，IC值范围为10.6±1.7至89.5±6.6μM（或>100μM）。进一步研究表明，4通过下调细胞周期蛋白A2、细胞周期蛋白依赖性激酶2的蛋白表达，导致SMMC7721细胞的S期细胞周期阻滞。同时，4通过下调Bcl-2的蛋白水平、上调Bax的水平并激活半胱天冬酶-3的裂解，诱导SMMC7721细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/17264600ee1a/d1ra06182h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/7163bf385ab3/d1ra06182h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/b8c56be7d879/d1ra06182h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/e2784186ddfd/d1ra06182h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/5e7725a47a30/d1ra06182h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/17264600ee1a/d1ra06182h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/7163bf385ab3/d1ra06182h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/b8c56be7d879/d1ra06182h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/e2784186ddfd/d1ra06182h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/5e7725a47a30/d1ra06182h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f516/9042891/17264600ee1a/d1ra06182h-f5.jpg

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本文引用的文献

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The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo.壮观链霉菌来源的壮观抑素对肝癌细胞的体内外增殖抑制作用。
Bioorg Chem. 2019 Dec;93:103311. doi: 10.1016/j.bioorg.2019.103311. Epub 2019 Sep 24.
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Total Synthesis of Lajollamycin B.拉霍拉霉素B的全合成
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