Chemical Engineering Department, Payame Noor University, 19395-4697 Tehran, Iran.
Chemistry Department, Payame Noor University, 19395-4697 Tehran, Iran.
Int J Biol Macromol. 2019 Jan;121:677-685. doi: 10.1016/j.ijbiomac.2018.10.106. Epub 2018 Oct 17.
In this study, a unique stimuli-responsive hydrogel nanocomposite was prepared via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid and N‑isopropyl acrylamide onto chitosan and subsequent in situ synthesis of magnetic FeO nanoparticles. In the next age, the structure and morphology of synthetic magnetic nanocomposite were characterized by FTIR, XRD, VSM, SEM, and TEM techniques. The modified hydrogel nanocomposite was employed as an excellent carrier for controlled releasing of anticancer drug doxorubicin (DOX). The results indicated that the maximum of DOX loading efficiency of nanocomposite was 89%. Notably, in vitro drug release studies showed that DOX was released in a sustained-release manner for the nanocomposites. From the results of in vitro release studies, dual temperature and pH responsiveness of the nanocomposite was demonstrated, and 82% of total DOX was released from the hydrogel within 2 days. Due to the unique structures and properties, the chitosan-based nanocomposite may be utilized as a promising drug carrier for controlled and sustained release of anticancer drugs.
在这项研究中，通过将丙烯酸和 N-异丙基丙烯酰胺接枝到壳聚糖上，并随后进行原位合成磁性 FeO 纳米粒子，制备了一种独特的刺激响应水凝胶纳米复合材料。在接下来的研究中，通过傅里叶变换红外光谱（FTIR）、X 射线衍射（XRD）、振动样品磁强计（VSM）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）技术对合成的磁性纳米复合材料的结构和形态进行了表征。将改性水凝胶纳米复合材料用作载体制备了用于控释抗癌药物阿霉素（DOX）的载体。结果表明，纳米复合材料的 DOX 负载效率最高可达 89%。值得注意的是，体外药物释放研究表明，纳米复合材料以持续释放的方式释放 DOX。从体外释放研究的结果来看，该纳米复合材料表现出双重温度和 pH 响应性，在 2 天内，水凝胶中释放了 82%的总 DOX。由于其独特的结构和性能，基于壳聚糖的纳米复合材料可用作控释和持续释放抗癌药物的有前途的药物载体。
