载 5-氟尿嘧啶的壳聚糖/聚丙烯酸/FeO 磁性纳米复合水凝胶作为一种潜在的抗癌药物输送系统。
5‑Fluorouracil loaded chitosan/polyacrylic acid/FeO magnetic nanocomposite hydrogel as a potential anticancer drug delivery system.
机构信息
Research Laboratory of Advanced Polymer Material, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran..
Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
出版信息
Int J Biol Macromol. 2019 Jul 1;132:506-513. doi: 10.1016/j.ijbiomac.2019.04.005. Epub 2019 Apr 3.
In most cancer treatments, chemotherapy is currently necessary; hence, more attention was devoted to developing new methods for designing drug delivery systems (DDS) with controlled drug release. For this aim, anticancer 5‑fluorouracil (5-FU) drug was loaded into chitosan/polyacrylic acid/FeO magnetic nanocomposite hydrogel (CS/PAA/FeO) through immersing in the drug solution. The prepared CS/PAA/FeO was characterized using FT-IR, XRD, VSM, TGA and SEM analysis. For demonstrating the efficiency of the prepared novel nanocomposite carrier as a controlled DDS, in-vitro the drug delivery tests were carried out in mimicking the colon and rectal conditions. The drug release tests showed that the CS/PAA/FeO enhanced the stability of drug dosing for a long time with controlled releases in the colon and rectal conditions. According to the obtained results, the prepared nanocomposite hydrogel could potentially to be used in DDS as a colon and rectal administration of 5-FU.
在大多数癌症治疗中，化疗目前是必要的；因此，更多的注意力被投入到开发新的方法来设计具有控制药物释放的药物输送系统（DDS）。为此，将抗癌药物 5-氟尿嘧啶（5-FU）载入壳聚糖/聚丙烯酸/FeO 磁性纳米复合水凝胶（CS/PAA/FeO）中，通过将其浸入药物溶液中。使用 FT-IR、XRD、VSM、TGA 和 SEM 分析对制备的 CS/PAA/FeO 进行了表征。为了证明所制备的新型纳米复合材料载体作为控制 DDS 的效率，在体外模拟结肠和直肠条件下进行了药物释放试验。药物释放试验表明，CS/PAA/FeO 增强了药物剂量的稳定性，可以长时间持续释放，并在结肠和直肠条件下进行控制释放。根据获得的结果，所制备的纳米复合水凝胶有可能作为 5-FU 的结肠和直肠给药的 DDS 使用。
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