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载热处理乳铁蛋白纳米粒的菊苣酸抗氧化性能的保持。

Preservation of Cichoric Acid Antioxidant Properties Loaded in Heat Treated Lactoferrin Nanoparticles.

机构信息

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100089, China.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.

出版信息

Molecules. 2018 Oct 18;23(10):2678. doi: 10.3390/molecules23102678.

DOI:10.3390/molecules23102678
PMID:30340329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6222800/
Abstract

In the current research, a new cichoric acid (CA) encapsulation system was investigated. The optimal condition for the formation of lactoferrin-cichoric acid nanoparticles (LF-CA NPs) was determined by controlling the solution pH, the thermal treatment conditions, and the concentration of CA. Fluorescence indicated that the electrostatic force and the hydrophobic force were the main forces in the formation of LF-CA NPs. LF-CA NPs prepared under different conditions were spherical in shape with smaller particle sizes and good zeta potential demonstrating good colloidal stability. Especially, the prepared particle size of the LF-CA NPs at pH 7 and 95 °C was about 67.20 ± 1.86 nm. The circular dichroism (CD) and the Fourier transform infrared spectroscopy (FTIR) results showed that the combination of LF (lactoferrin) and CA affected the secondary structure of the LF. The differential scanning calorimetry (DSC) results indicated that the addition of CA increased the thermal stability of LF. In vitro antioxidant experiments confirmed the antioxidant capacity of LF-CA NPs was better than CA. CA was successfully encapsulated into LF NPs with high encapsulated efficiency (97.87⁻99.87%) by high performance liquid chromatography (HPLC). These results showed that LF could be used as the wall material of CA with excellent nature.

摘要

在当前的研究中，考察了一种新的菊苣酸（CA）包封体系。通过控制溶液 pH 值、热处理条件和 CA 浓度，确定了乳铁蛋白-菊苣酸纳米粒（LF-CA NPs）形成的最佳条件。荧光表明，静电作用力和疏水作用力是 LF-CA NPs 形成的主要作用力。在不同条件下制备的 LF-CA NPs 呈球形，粒径较小，Zeta 电位较好，表现出良好的胶体稳定性。特别是在 pH 7 和 95°C 下制备的 LF-CA NPs 的粒径约为 67.20±1.86nm。圆二色性（CD）和傅里叶变换红外光谱（FTIR）结果表明，LF（乳铁蛋白）与 CA 的结合影响了 LF 的二级结构。差示扫描量热法（DSC）结果表明，CA 的加入提高了 LF 的热稳定性。体外抗氧化实验证实，LF-CA NPs 的抗氧化能力优于 CA。高效液相色谱法（HPLC）表明，CA 被成功包封到 LF NPs 中，包封效率高（97.87⁻99.87%）。这些结果表明，LF 可以用作 CA 的壁材，具有优异的性质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/6dfd96b5e3f8/molecules-23-02678-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/49007f6577dd/molecules-23-02678-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/20b465712ccc/molecules-23-02678-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/39b0ae7eca8b/molecules-23-02678-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/27d9072218e7/molecules-23-02678-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/9930df5f5a4e/molecules-23-02678-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/16f6699760ab/molecules-23-02678-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/3e8871478bc3/molecules-23-02678-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/486988c731aa/molecules-23-02678-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/6dfd96b5e3f8/molecules-23-02678-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/49007f6577dd/molecules-23-02678-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/20b465712ccc/molecules-23-02678-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/39b0ae7eca8b/molecules-23-02678-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/27d9072218e7/molecules-23-02678-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/9930df5f5a4e/molecules-23-02678-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/16f6699760ab/molecules-23-02678-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/3e8871478bc3/molecules-23-02678-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/486988c731aa/molecules-23-02678-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbc/6222800/6dfd96b5e3f8/molecules-23-02678-g009.jpg

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