Rohdin C, Häggström J, Ljungvall I, Nyman Lee H, De Decker S, Bertram S, Lindblad-Toh K, Hultin Jäderlund K
Department of Clinical Sciences, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden; Anicura, Albano Small Animal Hospital, Rinkebyvägen 21, 182 36 Danderyd, Sweden.
Department of Clinical Sciences, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.
Vet J. 2018 Nov;241:24-30. doi: 10.1016/j.tvjl.2018.09.008. Epub 2018 Sep 13.
Congenital vertebral malformations (CVMs) are common in brachycephalic dogs such as the pug, and are often considered incidental findings. However, specific CVMs have been suggested to be associated with neurological deficits in pugs. The objective of this study was to investigate the clinical importance of CVMs in the pug by comparing computed tomography studies of the thoracolumbar spine from pugs without neurological deficits with those from pugs with a confirmed T3-L3 spinal cord lesion and neurological deficits consistent with a chronic T3-L3 myelopathy. A total of 57 pugs were recruited into the study from Sweden (n=33), United Kingdom (n=21) and Norway (n=3); 30 with neurological deficits and 27 without. Focal T3-L3 pathology was confirmed in all pugs with neurological deficits by magnetic resonance imaging (n=29) and/or pathology (n=15). Computed tomography studies of the thoracolumbar spine from pugs with and without neurological deficits were compared to investigate possible associations between presentation of neurological deficits consistent with chronic T3-L3 pathology and signalment variables, presence of CVMs and type of CVMs. Congenital vertebral malformations were as common in pugs with, as in pugs without, neurological deficits. Regardless of neurological status, the majority of pugs (96%) presented with one or more CVM. An association between presence, or type of CVM in the T1-L3 vertebral column, and neurological deficits consistent with T3-L3 pathology could not be confirmed.
先天性椎体畸形（CVMs）在短头犬如哈巴狗中很常见，通常被视为偶然发现。然而，特定的CVMs被认为与哈巴狗的神经功能缺损有关。本研究的目的是通过比较无神经功能缺损的哈巴狗与经证实有T3-L3脊髓病变且神经功能缺损与慢性T3-L3脊髓病一致的哈巴狗的胸腰椎计算机断层扫描研究，来调查CVMs在哈巴狗中的临床重要性。共有57只哈巴狗从瑞典（n=33）、英国（n=21）和挪威（n=3）被招募到该研究中；30只有神经功能缺损，27只没有。通过磁共振成像（n=29）和/或病理学（n=15）在所有有神经功能缺损的哈巴狗中证实了局灶性T3-L3病变。比较了有和无神经功能缺损的哈巴狗的胸腰椎计算机断层扫描研究，以调查与慢性T3-L3病变一致的神经功能缺损表现与信号变量、CVMs的存在和CVMs的类型之间的可能关联。先天性椎体畸形在有神经功能缺损的哈巴狗和无神经功能缺损的哈巴狗中一样常见。无论神经状态如何，大多数哈巴狗（96%）都有一个或多个CVM。无法证实T1-L3椎体柱中CVM的存在或类型与与T3-L3病变一致的神经功能缺损之间存在关联。
