Fisher Stephen C, Shores Andy, Simpson Stephen T
Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.
J Am Vet Med Assoc. 2013 Jan 15;242(2):223-9. doi: 10.2460/javma.242.2.223.
To report thoracolumbar caudal articular process malformations with secondary constrictive fibrosis of the spinal cord in Pugs.
Retrospective case series.
11 Pugs with neurologic dysfunction resulting from constriction of fibrous tissue secondary to thoracolumbar caudal articular process malformation and 5 Pugs with no neurologic dysfunction.
Medical records of dogs with myelopathy presumably caused by constriction of fibrous tissue secondary to thoracolumbar caudal articular process malformation at 2 referral institutions between 1993 and 2009 were reviewed. Dogs were included in the study if hypoplastic or aplastic thoracolumbar caudal articular processes were present on radiographs, CT images, or MRI images.
The most common neurologic examination findings were paraparesis with ataxia or paraplegia but no evidence of hyperpathia along the vertebral column. All dogs' neurologic lesion localization was to the T3-L3 spinal cord segments. Median age at examination was 7. 7 years (range, 2 to 11 years). Five of 11 dogs had a history of unrelated trauma. Four of 11 dogs had urinary or fecal incontinence. Eight of 11 dogs underwent surgical exploration. Despite surgical intervention, all dogs that survived surgery continued to have neurologic deficits.
In the present study, presence of aplastic or hypoplastic articular processes in the thoracolumbar region did not always produce neurologic signs. However, fibrous constrictive myelopathy should be considered in Pugs with pelvic limb gait and postural reaction deficits and lack of hyperpathia upon palpation of the vertebral column. Additional studies are warranted to further characterize the disease process and determine the most effective means of treatment.
报告哈巴狗胸腰椎尾侧关节突畸形伴继发性脊髓缩窄性纤维化的情况。
回顾性病例系列研究。
11只因胸腰椎尾侧关节突畸形继发纤维组织压迫而出现神经功能障碍的哈巴狗，以及5只无神经功能障碍的哈巴狗。
回顾了1993年至2009年间两家转诊机构中疑似由胸腰椎尾侧关节突畸形继发纤维组织压迫引起脊髓病的犬只的病历。如果在X线片、CT图像或MRI图像上存在发育不全或发育不良的胸腰椎尾侧关节突，则将这些犬纳入研究。
最常见的神经学检查结果是伴有共济失调的轻瘫或截瘫，但沿脊柱无感觉过敏的证据。所有犬的神经病变定位均在T3-L3脊髓节段。检查时的中位年龄为7.7岁（范围为2至11岁）。11只犬中有5只曾有过无关的外伤史。11只犬中有4只存在大小便失禁。11只犬中有8只接受了手术探查。尽管进行了手术干预，但所有术后存活的犬仍有神经功能缺损。
在本研究中，胸腰椎区域关节突发育不全或发育不良并不总是会产生神经学体征。然而，对于出现后肢步态和姿势反应缺陷且触诊脊柱时无感觉过敏的哈巴狗，应考虑纤维性缩窄性脊髓病。需要进一步研究以更全面地描述该疾病过程并确定最有效的治疗方法。
