Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Anicura Albano Small Animal Hospital, Danderyd, Sweden.
J Vet Intern Med. 2020 Mar;34(2):797-807. doi: 10.1111/jvim.15716. Epub 2020 Jan 31.
Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs.
To further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy.
Thirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study.
Prospective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death.
Twenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs.
Meningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy.
与脊髓和脊柱病变相关的胸腰椎脊髓病，具有相似的临床表型，但病因不同，发生在哈巴狗中。
进一步描述具有长期胸腰椎脊髓病的哈巴狗的临床和神经病理学特征。
本研究纳入了 30 只具有超过一个月的共济失调和骨盆肢体瘫痪病史的纯种哈巴狗，提示脊髓病变局限于胸腰椎。
前瞻性临床病理研究。纳入的哈巴狗接受了全面的神经学检查以及脊髓的大体和组织病理学尸检研究。在死亡前或死亡后立即进行了计算机断层扫描（n = 18）、磁共振成像（n = 17）和脑脊液分析（n = 27）。
20 只雄性和 10 只雌性哈巴狗在临床发病时的中位年龄为 84 个月（四分位距，66-96）。受影响的哈巴狗呈现进行性临床病程，80%的哈巴狗出现大小便失禁。在 30 只哈巴狗中有 24 只出现了胸腰椎脊髓的脑膜纤维化伴局灶性、软化性、神经实质破坏。与局灶性脊髓病变相邻的椎体病变，以及在 43%的哈巴狗中存在与实质病变相关或不相关的淋巴组织细胞炎症。
脑膜纤维化伴相关局灶性脊髓破坏和邻近的脊柱病变是具有长期胸腰椎脊髓病的哈巴狗的常见表现。
