Jones J F, Straus S E
Annu Rev Med. 1987;38:195-209. doi: 10.1146/annurev.me.38.020187.001211.
The Epstein-Barr virus (EBV) has been associated with classic infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and B-cell lymphomas in primary and secondary immunodeficiency disease. The availability of specific serologic diagnosis of EBV, rather than dependence on heterophile antibody positivity, has broadened the scope of EBV-associated diseases. A chronic neuroasthenia syndrome accompanied by antibody titers to the viral capsid antigen and early antigen of EBV, which are higher than found in asymptomatic individuals, is one such additional EBV-associated syndrome. This paper describes the clinical and laboratory responses to EBV that are present in this chronic syndrome. It then discusses management of these patients and the difficulties in establishing a cause-and-effect relationship between EBV and chronic neuroasthenia along with recommendations for future studies.
爱泼斯坦-巴尔病毒（EBV）与经典传染性单核细胞增多症、伯基特淋巴瘤、鼻咽癌以及原发性和继发性免疫缺陷疾病中的B细胞淋巴瘤有关。EBV特异性血清学诊断方法的出现，而非依赖嗜异性抗体阳性，拓宽了EBV相关疾病的范围。一种伴有针对EBV病毒衣壳抗原和早期抗原的抗体滴度高于无症状个体的慢性神经衰弱综合征就是这样一种额外的EBV相关综合征。本文描述了这种慢性综合征中存在的对EBV的临床和实验室反应。然后讨论了这些患者的管理以及在确立EBV与慢性神经衰弱之间的因果关系方面所面临的困难，并给出了未来研究的建议。
