金疗法中使用的金（I）盐对人中性粒细胞胶原酶的抑制作用。

Inhibition of human neutrophil collagenase by gold(I) salts used in chrysotherapy.

作者信息

Mallya S K, Van Wart H E

出版信息

Biochem Biophys Res Commun. 1987 Apr 14;144(1):101-8. doi: 10.1016/s0006-291x(87)80481-3.

Abstract

Six gold(I) salts, some of which are used as drugs in chrysotherapy, are shown to be inhibitors of two forms of human neutrophil collagenase. The IC50 values vary over six orders of magnitude, the lowest being 3.5 nM for Myocrisin. Thus, inhibition is greatly affected by the identity of the ligands to the gold(I) atom. The inhibition of collagenase by these gold(I) salts may be a partial basis for their antiarthritic action.

摘要

六种金（I）盐，其中一些在金疗法中用作药物，已被证明是两种形式的人中性粒细胞胶原酶的抑制剂。IC50值在六个数量级范围内变化，最低的是Myocrisin的3.5 nM。因此，抑制作用受金（I）原子配体的身份影响很大。这些金（I）盐对胶原酶的抑制作用可能是其抗关节炎作用的部分基础。