Laboratory of National Experimental Teaching and Demonstration Center of Basic Medicine, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu Province, China.
Research Center for Neurobiology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu Province, China.
Inflammation. 2019 Apr;42(2):586-597. doi: 10.1007/s10753-018-0915-3.
Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system that is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. Hydrogen-rich saline (HRS) is efficacious in preventive and therapeutic applications for many disorders because of its antioxidant and anti-inflammatory properties. Here, we determined the effect of HRS in experimental autoimmune encephalomyelitis (EAE), which is a generally accepted model of the immuno-pathogenic mechanisms underlying MS. We found that HRS reduced the severity of EAE in mice and alleviated inflammation and demyelination. Furthermore, treatment with HRS attenuated oxidative stress in EAE mice. Finally, the results of our study suggest that activation of the Nrf2-ARE pathway plays a critical role in the protective effects of HRS in EAE mice.
多发性硬化症（MS）是一种中枢神经系统的慢性炎症性疾病，其特征是脱髓鞘、神经退行性变和对氧化应激的敏感性。富氢盐水（HRS）因其抗氧化和抗炎特性，在许多疾病的预防和治疗应用中都非常有效。在这里，我们确定了 HRS 在实验性自身免疫性脑脊髓炎（EAE）中的作用，EAE 是一种公认的多发性硬化症免疫发病机制模型。我们发现 HRS 可降低小鼠 EAE 的严重程度，并减轻炎症和脱髓鞘。此外，HRS 治疗可减轻 EAE 小鼠的氧化应激。最后，我们的研究结果表明，Nrf2-ARE 通路的激活在 HRS 对 EAE 小鼠的保护作用中起着关键作用。
