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长链非编码 RNA MAPKAPK5-AS1 通过部分沉默 p21 表达促进结直肠癌细胞增殖。

Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer proliferation by partly silencing p21 expression.

机构信息

Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.

The Second Clinical Medical College of Nanjing Medical University, Nanjing, China.

出版信息

Cancer Sci. 2019 Jan;110(1):72-85. doi: 10.1111/cas.13838. Epub 2018 Dec 4.

DOI:10.1111/cas.13838
PMID:30343528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6317943/
Abstract

Colorectal cancer (CRC) is the third most common malignancy in the world, and long noncoding RNA (lncRNA) plays a critical role in carcinogenesis. Here, we report a novel lncRNA, MAPKAPK5-AS1, that acts as a critical oncogene in CRC. In addition, we attempted to explore the functions of MAPKAPK5-AS1 on tumor progression in vitro and in vivo. Quantitative RT-PCR was used to examine the expression of MAPKAPK5-AS1 in CRC tissues and cells. Expression of MAPKAPK5-AS1 was significantly upregulated in 50 CRC tissues, and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stage in CRC patients. Knockdown of MAPKAPK5-AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. We also found that p21 is a target of MAPKAPK5-AS1. In addition, we are the first to report that MAPKAPK5-AS1 plays a carcinogenic role in CRC. MAPKAPK5-AS1 is a novel prognostic biomarker and a potential therapeutic candidate for CRC cancer.

摘要

结直肠癌（CRC）是世界上第三大常见恶性肿瘤，长链非编码 RNA（lncRNA）在致癌作用中发挥着关键作用。在这里，我们报告了一种新型的 lncRNA，MAPKAPK5-AS1，它在 CRC 中作为一种关键的癌基因发挥作用。此外，我们试图探索 MAPKAPK5-AS1 在体外和体内对肿瘤进展的功能。定量 RT-PCR 用于检测 CRC 组织和细胞中 MAPKAPK5-AS1 的表达。MAPKAPK5-AS1 在 50 个 CRC 组织中表达显著上调，并且在 CRC 患者中发现 MAPKAPK5-AS1 的高表达与更大的肿瘤大小和更先进的病理阶段相关。MAPKAPK5-AS1 的敲低显著抑制 CRC 细胞的增殖并诱导细胞凋亡。我们还发现 p21 是 MAPKAPK5-AS1 的靶标。此外，我们首次报道 MAPKAPK5-AS1 在 CRC 中发挥致癌作用。MAPKAPK5-AS1 是 CRC 的一种新型预后生物标志物和潜在的治疗候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/3edcf5354820/CAS-110-72-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/d8cb78c679f2/CAS-110-72-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/44471851e3e5/CAS-110-72-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/24bfa662c20e/CAS-110-72-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/52817f4cfa5d/CAS-110-72-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/a0dd0e562070/CAS-110-72-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/5a0651939709/CAS-110-72-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/3edcf5354820/CAS-110-72-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/d8cb78c679f2/CAS-110-72-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/44471851e3e5/CAS-110-72-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/24bfa662c20e/CAS-110-72-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/52817f4cfa5d/CAS-110-72-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/a0dd0e562070/CAS-110-72-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/5a0651939709/CAS-110-72-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d9/6317943/3edcf5354820/CAS-110-72-g007.jpg

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