TUG1 通过作为 miR-26a 的 ceRNA 促进前列腺癌进展。
TUG1 promotes prostate cancer progression by acting as a ceRNA of miR-26a.
机构信息
Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R. China.
Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R. China.
出版信息
Biosci Rep. 2018 Oct 2;38(5). doi: 10.1042/BSR20180677. Print 2018 Oct 31.
Previous studies have demonstrated that taurine-upregulated gene 1 (TUG1) was aberrantly expressed and involved in multiple types of cancer; however, the expression profile and potential role of TUG1 in prostate cancer (PCa) remains unclear. The aim of the present study was to evaluate the expression and function of TUG1 in PCa. In the present study, we analyzed TUG1 expression levels of PCa patients in tumor and adjacent normal tissue by real-time quantitative PCR. Knockdown of TUG1 by RNAi was performed to explore its roles in cell proliferation, migration, and invasion. Here we report, for the first time, that TUG1 promotes tumor cell migration, invasion, and proliferation in PCa by working in key aspects of biological behaviors. TUG1 could negatively regulate the expression of miR-26a in PCa cells. The bioinformatics prediction revealed putative miR-26a-binding sites within TUG1 transcripts. In conclusion, our study suggests that long non-coding RNA (lncRNA) TUG1 acts as a functional oncogene in PCa development.
先前的研究表明，牛磺酸上调基因 1（TUG1）表达异常，参与多种类型的癌症；然而，TUG1 在前列腺癌（PCa）中的表达谱和潜在作用尚不清楚。本研究旨在评估 TUG1 在 PCa 中的表达和功能。在本研究中，我们通过实时定量 PCR 分析了 PCa 患者肿瘤和相邻正常组织中的 TUG1 表达水平。通过 RNAi 敲低 TUG1 以探索其在细胞增殖、迁移和侵袭中的作用。在这里，我们首次报道，TUG1 通过在生物学行为的关键方面起作用，促进 PCa 中的肿瘤细胞迁移、侵袭和增殖。TUG1 可以负调控 PCa 细胞中 miR-26a 的表达。生物信息学预测显示 TUG1 转录本中存在潜在的 miR-26a 结合位点。总之，我们的研究表明，长链非编码 RNA（lncRNA）TUG1 在 PCa 发展中作为功能性癌基因发挥作用。
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