Myhre K, Cabanac M, Myhre G
Acta Physiol Scand. 1977 Oct;101(2):219-29. doi: 10.1111/j.1748-1716.1977.tb06001.x.
The skin and colonic temperatures were recorded in frogs (Rana esculenta) which had selected a suitable microenvironment in a box filled with 2-3 cm water. The water temperatures ranged from 0 degrees C to + 40 degrees C. Such measurements were performed before and after intraperitoneal injections of killed pathogenic bacteria (M. xenopi and M. range), killed non-pathogenic bacteria (M. aquae II) and 0.9% sterile saline, intraperitoneal injections of blood plasma from frogs pre-injected with killed M. ranae, injections of PGE1 into the brain. The injections of pathogenic bacterial endotoxin caused, after latencies of 5-120 min, higher preferred water temperatures, which produced an average maximum colonic temperature increase of 6.5 degrees C +/- 1.0 degrees C (S.E.) (p less than 0.001). The non-pathogenic bacteria and sterile saline caused no temperature change. Monophasic hyperthermia of shorter latency was caused by injections of blood plasma from frog preinjected with M. ranae. Monophasic hyperthermia of the shortest latency was observed after diencephalic injections of PGE1. Based on their similarity we suggest that ectothermic and endothermic fever have a common phylogenetic origin.
在装有2 - 3厘米深的水的盒子里，对已选择适宜微环境的食用蛙（Rana esculenta）的皮肤温度和结肠温度进行记录。水温范围为0摄氏度至40摄氏度。在腹腔注射灭活的病原菌（非洲绿猴分枝杆菌和蛙分枝杆菌）、灭活的非病原菌（水生分枝杆菌II）和0.9%无菌生理盐水之后，在腹腔注射预先注射了灭活蛙分枝杆菌的青蛙的血浆之后，以及向脑部注射前列腺素E1之后，进行这样的测量。注射病原菌内毒素后，经过5 - 120分钟的潜伏期，出现较高的偏好水温，导致结肠温度平均最大升高6.5摄氏度±1.0摄氏度（标准误）（p < 0.001）。非病原菌和无菌生理盐水未引起温度变化。预先注射蛙分枝杆菌的青蛙的血浆注射导致潜伏期较短的单相热。在间脑注射前列腺素E1后观察到潜伏期最短的单相热。基于它们的相似性，我们认为变温动物和恒温动物的发热有共同的系统发育起源。
