抗肿瘤大环内酯类化合物劳利霉素的合成研究：通过催化杂环狄尔斯-阿尔德策略对C-C片段进行对映选择性合成。
SYNTHETIC STUDIES OF ANTITUMOR MACROLIDE LAULIMALIDE: ENANTIOSELECTIVE SYNTHESIS OF THE C-C SEGMENT BY A CATALYTIC HETERO DIELS-ALDER STRATEGY.
作者信息
Ghosh Arun K, Mathivanan Packiarajan, Cappiello John
机构信息
Department of Chemisüy, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607.
出版信息
Tetrahedron Lett. 1997 Apr 7;38(14):2427-2430. doi: 10.1016/S0040-4039(97)00416-4. Epub 2000 Mar 17.
Abstract
The C-C segment of the novel antitumor agent laulimalide has been constructed enantioselectively by utilizing a catalytic asymmetric hetero Diels-Alder reaction of benzyloxyacetaldehyde and Danishefsky's diene followed by Ferrier rearrangement and asymmetric conjugate reaction as the key steps.
摘要
新型抗肿瘤药物劳利霉素的C-C片段已通过以下关键步骤对映选择性构建：利用苄氧基乙醛与丹尼谢夫斯基二烯的催化不对称杂Diels-Alder反应，随后进行费里尔重排和不对称共轭反应。
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