Medina Jorge H, Viola Haydee
Instituto de Biología Celular y Neurociencias (IBCN) "Dr Eduardo De Robertis", CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Departamento de Fisiología, Biología Molecular y Celular "Dr. Hector Maldonado" (FBMC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Front Mol Neurosci. 2018 Oct 5;11:361. doi: 10.3389/fnmol.2018.00361. eCollection 2018.
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.
细胞外调节激酶1/2（ERK1/2）与多种细胞过程密切相关。在大脑中，ERK1/2的活性主要参与长期记忆（LTM）的形成和表达。在此，我们回顾早期证据，并描述ERK1/2信号在记忆处理中的最新进展，重点关注ERK1/2在记忆检索和重新巩固以及记忆痕迹维持中的作用，包括涉及保护不稳定记忆的机制。此外，重新学习需要特定脑区的ERK1/2活性。其在不同记忆阶段的参与表明，ERK1/2是记忆处理的核心要素，也是治疗与神经疾病相关的记忆障碍的一个可能靶点。
