Azad Meghan B, Wade Kaitlin H, Timpson Nicholas J
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Children's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, R3E 3P4, Canada.
Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.
Wellcome Open Res. 2018 Sep 25;3:65. doi: 10.12688/wellcomeopenres.14636.2. eCollection 2018.
The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. , ) and susceptibility to others (e.g. , ). Non-secretors also have an increased risk of type 1 diabetes and inflammatory bowel disease. We examined genotype, infections and chronic conditions in a population-based cohort. We studied 7,582 pregnant women from the ALSPAC pregnancy cohort. Infections (measles, mumps, chicken pox, whooping cough, meningitis, herpes, gonorrhea and urinary infections) and chronic conditions (kidney disease, hypertension, diabetes, rheumatism, arthritis, psoriasis, hay fever, asthma, eczema and allergies) were self-reported. secretor status was determined from the rs601338 genotype. ABO blood type was obtained from clinical records. Overall, 1920 women (25.3%) were homozygous for the non-secretor allele (AA). Secretor status was associated with mumps, with 68% of non-secretors experiencing this infection, compared to 48% of secretors (RR, 1.40; 95% CI, 1.34-1.46). A weaker association was observed for measles infection (76% vs. 72%; RR, 1.05; 95% CI, 1.02-1.09). Non-secretors also experienced an increased risk of kidney disease (5.4% vs. 3.9%; RR, 1.39; 95% CI, 1.11-1.75). Independent of secretor status, AB blood type was a risk factor for mumps (RR 1.15; 95%CI, 1.03, 1.28 compared to type O). We found no evidence of interaction between secretor status and blood type. For some conditions, including asthma and arthritis, heterozygosity (GA) appeared to confer an intermediate phenotype. There was no strong evidence of association between secretor status and other infections or chronic conditions, although statistical power was limited for rare outcomes. Our results identify an association between secretor status and self-reported kidney disease, and confirm a recently reported association with susceptibility to mumps infection. The clinical implications of these associations warrant further investigation.
岩藻糖基转移酶-2（Fucosyltransferase-2）基因决定血型分泌者状态。对于无活性的“非分泌者”rs601338(A)等位基因纯合会使人对某些感染（如……）具有抵抗力，而对其他感染（如……）易感。非分泌者患1型糖尿病和炎症性肠病的风险也会增加。我们在一个基于人群的队列中研究了该基因型、感染情况和慢性病状况。我们研究了来自阿冯纵向父母与儿童发育研究（ALSPAC）妊娠队列的7582名孕妇。感染（麻疹、腮腺炎、水痘、百日咳、脑膜炎、疱疹、淋病和泌尿系统感染）和慢性病（肾病、高血压、糖尿病、风湿病、关节炎、银屑病、花粉症、哮喘、湿疹和过敏）均通过自我报告获取。分泌者状态由rs601338基因型确定。ABO血型从临床记录中获取。总体而言，1920名女性（25.3%）为非分泌者等位基因（AA）纯合子。分泌者状态与腮腺炎有关，68%的非分泌者感染过腮腺炎，而分泌者的这一比例为48%（相对风险，1.40；95%置信区间，1.34 - 1.46）。对于麻疹感染，观察到的关联较弱（76%对72%；相对风险，1.05；95%置信区间，1.02 - 1.09）。非分泌者患肾病的风险也增加（5.4%对3.9%；相对风险，1.39；95%置信区间，1.11 - 1.75）。与分泌者状态无关，AB血型是患腮腺炎的一个风险因素（与O型血相比，相对风险1.15；95%置信区间，1.03，1.28）。我们没有发现分泌者状态与血型之间存在相互作用的证据。对于某些疾病，包括哮喘和关节炎，杂合子（GA）似乎表现出一种中间表型。虽然对于罕见结果统计效力有限，但没有强有力的证据表明分泌者状态与其他感染或慢性病之间存在关联。我们的结果确定了分泌者状态与自我报告的肾病之间存在关联，并证实了最近报道的与腮腺炎感染易感性之间的关联。这些关联的临床意义值得进一步研究。
