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岩藻糖基转移酶3基因多态性与炎症性肠病相关：一项系统评价

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review.

作者信息

Zheng Jiansheng, Zhu Tang

机构信息

Department of Public Health, School of Basic Medical Science, Putian University, Putian, Fujian 351100, China.

Key Laboratory of Translational Tumor Medicine in Fujian Province, School of Basic Medical Science, Putian University, Putian, Fujian 351100, China.

出版信息

Asian Biomed (Res Rev News). 2023 Sep 17;17(2):45-54. doi: 10.2478/abm-2023-0044. eCollection 2023 Apr.

DOI:10.2478/abm-2023-0044
PMID:37719320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10505062/
Abstract

BACKGROUND

Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility.

OBJECTIVE

To investigate the association between gene polymorphisms and IBD.

METHODS

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0.

RESULTS

The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]: genotype () 0.84 (0.72-0.97), () 1.93 (1.23-3.05), () 2.38 (1.52-3.74), () 0.84 (0.73-0.96); genotype () 1.03 (0.87-1.23), () 1.19 (0.56-2.51), () 1.19 (0.56-2.51), () 1.02 (0.86-1.20); genotype () 0.98 (0.85-1.12), () 1.20 (0.90-1.61), () 1.21 (0.90-1.62), () 0.96 (0.86-1.07). Sensitivity analysis indicated the stability of the results, and Egger analysis showed no significant publication bias.

CONCLUSIONS

The gene polymorphism may be associated with IBD susceptibility, whereas the and gene polymorphisms may not be associated with IBD.

摘要

背景

炎症性肠病（IBD）是一种遗传基础不明的疾病。岩藻糖基转移酶3（FUT3）可能与IBD易感性有关。

目的

研究基因多态性与IBD之间的关联。

方法

按照系统评价和Meta分析的首选报告项目（PRISMA）2020清单以及人群、干预措施、对照、结局和研究（PICOS）指南，检索截至2020年4月30日发表的病例对照研究。两名独立的审阅者使用纽卡斯尔-渥太华量表进行筛选、数据提取和质量评估。使用RevMan和Stata12.0进行Meta分析、敏感性分析和Egger检验。

结果

该综述纳入了5篇文章和12项病例对照研究，涉及1712例IBD患者和1903例对照。Meta分析得出以下合并比值比[95%置信区间]：基因型（）0.84（0.72 - 0.97），（）1.93（1.23 - 3.05），（）2.38（1.52 - 3.74），（）0.84（0.73 - 0.96）；基因型（）1.03（0.87 - 1.23），（）1.19（0.56 - 2.51），（）1.19（0.56 - 2.51），（）1.02（0.86 - 1.20）；基因型（）0.98（0.85 - 1.12），（）1.20（0.90 - 1.61），（）1.21（0.90 - 1.62），（）0.96（0.86 - 1.07）。敏感性分析表明结果具有稳定性，Egger分析显示无显著的发表偏倚。

结论

基因多态性可能与IBD易感性相关，而基因多态性可能与IBD无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/90b220c219eb/j_abm-2023-0044_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/5bd6651427fe/j_abm-2023-0044_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/63dc34a7ba06/j_abm-2023-0044_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/9d6b6f8bfd0e/j_abm-2023-0044_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/90b220c219eb/j_abm-2023-0044_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/5bd6651427fe/j_abm-2023-0044_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/63dc34a7ba06/j_abm-2023-0044_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/9d6b6f8bfd0e/j_abm-2023-0044_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8db2/10505062/90b220c219eb/j_abm-2023-0044_fig_004.jpg

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