El Colegio Nacional and Facultad de Ciencias , Universidad Nacional Autónoma de México , Mexico City 04510 , Mexico.
ACS Nano. 2018 Oct 23;12(10):9643-9647. doi: 10.1021/acsnano.8b07605. Epub 2018 Oct 15.
Prebiotic evolution is the stage that is assumed to have taken place prior to the emergence of the first living entities, during which time the abiotic synthesis of monomers, oligomers, and supramolecular systems that led to the hypothesized RNA world occurred. In this Perspective, the success of one-pot Miller-Urey type synthesis of organic compounds is compared with the multipot syntheses developed within the framework of systems chemistry, which attempts to demonstrate that RNA could have been formed directly in the primitive environment. The prebiotic significance of liquid-crystal ordering of nucleic acid oligomers and self-organizing assemblages of RNA and DNA that are formed in the absence of membranes or mineral matrices is also addressed.
前生物进化是指在第一个生命实体出现之前所经历的阶段，在此期间，单体、低聚物和超分子系统的非生物合成导致了假设的 RNA 世界的出现。在这个观点中，一锅式米勒-尤里型有机化合物合成的成功与系统化学框架内发展的多潜能合成进行了比较，试图证明 RNA 可以直接在原始环境中形成。还讨论了在没有膜或矿物基质的情况下形成的核酸低聚物的液晶有序化和 RNA 和 DNA 的自组织组装的前生物意义。
