Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Trends Mol Med. 2018 Nov;24(11):942-949. doi: 10.1016/j.molmed.2018.09.002. Epub 2018 Oct 19.
Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets.
产后（或产褥期）精神病（PP）是一种罕见的严重精神障碍，在分娩后不久影响女性；有双相情感障碍或 PP 病史的个体风险特别高，但潜在的病理生理学仍知之甚少。新出现的证据表明，免疫系统（功能）障碍在疾病发作中起重要作用。基于临床和动物模型研究的新发现，我们假设调节性 T 细胞的丰度和/或活性，以及 CCN 蛋白介导的大脑中随后（再）髓鞘形成过程的功效在 PP 中受到干扰；该途径可能受到该疾病的风险和保护/治疗因素的调节，并且识别其中的异常可能标志着新的预测生物标志物和治疗靶点。
