产后精神病中的免疫系统异常：来自印度一家三级神经精神病医院的免疫表型研究。
Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India.
作者信息
Kumar Mahesh M, Venkataswamy Manjunatha M, Sathyanarayanan Gopinath, Thippeswamy Harish, Chandra Prabha S, Mani Reeta S
机构信息
Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India.
Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India.
出版信息
J Neuroimmunol. 2017 Sep 15;310:8-13. doi: 10.1016/j.jneuroim.2017.06.002. Epub 2017 Jun 15.
Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T cells, while activated CD8 and memory regulatory T cells (Tregs) were increased in women with PP as against healthy controls. The CD14CD16non-classical monocytes, CD11c+myeloid DCs and cytotoxic CD56CD16 were reduced, while CD56CD16regulatory NK cells were elevated in women with PP. The variations in immune cell subsets highlight the generalized immune dysregulation in PP.
产后精神病（PP）对母亲和婴儿均有显著的发病率。最近的研究报道了产后精神病期间免疫系统失调的情况。本研究试图通过流式细胞术确定与首次发作的产后精神病相关的免疫特征。与健康对照组相比，产后精神病女性的外周血中初始CD4和CD8 T细胞减少，而活化的CD8和记忆调节性T细胞（Tregs）增加。产后精神病女性的CD14CD16非经典单核细胞、CD11c + 髓样树突状细胞和细胞毒性CD56CD16减少，而CD56CD16调节性自然杀伤细胞升高。免疫细胞亚群的变化突出了产后精神病中普遍存在的免疫失调。
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