Chen Shu-Wei, Zhang Quan, Guo Zhu-Ming, Chen Wen-Kuan, Liu Wei-Wei, Chen Yan-Feng, Li Qiu-Li, Liu Xue-Kui, Li Hao, Ou-Yang Dian, Chen Wei-Chao, Fu Xiao-Yan, Wang Xi-Di, Yang An-Kui, Bei Jin-Xin, Song Ming
Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center,
State Key Laboratory of Oncology in South China,
Cancer Manag Res. 2018 Oct 12;10:4523-4535. doi: 10.2147/CMAR.S171251. eCollection 2018.
Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China.
Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960-1969 (n=253), 1970-1979 (n=497), 1980-1989 (n= 659), 1990-1999 (n=793), and 2000-2009 (n=1,160) at the Sun Yat-sen University Cancer Center.
Over time, the overall 5-year survival rate for OCC patients was 52.0%. According to tumor localization, this rate was 71.4% for lip cancer, 56.3% for oral tongue cancer, and 42.7% for other parts of the oral cavity. From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8% to 55.6% (<0.001). Survival steadily decreased with age and was higher for women than for men in the 3 most recent decades. The survival rate for male patients was constant over time, while the rate for female patients improved dramatically. Obvious trends in clinical features over time included the following: increasing age of patients, increasing proportions of localized disease at diagnosis, decreasing proportions of diagnoses of lip cancer, decreasing proportions of diagnoses of squamous cell carcinoma, and decreasing proportions of non-surgical treatment approaches.
The survival rate has steadily improved for OCC patients at this cancer center.
全球数据显示口腔癌（OCC）患者的生存率改善甚微。我们想了解在中国一家大型癌症中心接受初始治疗和随访的OCC患者的临床特征和生存率是否随时间发生了变化。
收集了1960 - 1969年（n = 253）、1970 - 1979年（n = 497）、1980 - 1989年（n = 659）、1990 - 1999年（n = 793）以及2000 - 2009年（n = 1160）在中山大学癌症中心确诊的患者的临床特征和生存数据。
随着时间推移，OCC患者的总体5年生存率为52.0%。根据肿瘤部位，唇癌的这一比例为71.4%，口腔舌癌为56.3%，口腔其他部位为42.7%。从20世纪60年代到21世纪初，5年生存率从47.8%稳步提高到55.6%（<0.001）。生存率随年龄增长而稳步下降，在最近三十年中女性生存率高于男性。男性患者的生存率随时间保持不变，而女性患者的生存率则显著提高。随着时间推移，临床特征的明显趋势包括：患者年龄增加、诊断时局部疾病比例增加、唇癌诊断比例下降、鳞状细胞癌诊断比例下降以及非手术治疗方法比例下降。
该癌症中心的OCC患者生存率稳步提高。
