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复合丝-细胞外基质支架促进间充质干细胞的软骨生成。

Composite Silk-Extracellular Matrix Scaffolds for Enhanced Chondrogenesis of Mesenchymal Stem Cells.

机构信息

1 Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University , Nanjing, China .

2 Department of Orthopedics, Yixing People's Hospital , Yixing, China .

出版信息

Tissue Eng Part C Methods. 2018 Nov;24(11):645-658. doi: 10.1089/ten.TEC.2018.0199.

DOI:10.1089/ten.TEC.2018.0199
PMID:30351193
Abstract

This study presented a new method to fabricate SF-ECM scaffolds that potentially promote chondrogenesis of BMSCs, and open up new possibilities for using SF-ECM scaffolds as an off-the-shelf strategy for joint cartilage regeneration. It is worthy of further investigation in knee joints of animals, and beyond knee cartilage, this scaffold may also serve as an ideal biomaterial for the regeneration of other joint cartilages.

摘要

本研究提出了一种新的方法来制备 SF-ECM 支架,该支架可能促进 BMSCs 的软骨生成,为使用 SF-ECM 支架作为关节软骨再生的现成策略开辟了新的可能性。值得在动物膝关节中进一步研究,而且除了膝关节软骨外,这种支架也可能成为其他关节软骨再生的理想生物材料。

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