肥胖在炎症性肠病中的作用。

The role of obesity in inflammatory bowel disease.

机构信息

Department of Molecular and Cell Biology, The Centre for Molecular Therapeutics, James Cook University, Australian Institute of Tropical Health and Medicine, Townsville, QLD 4811, Australia.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia; Blacktown Clinical School, Western Sydney University, Blacktown Hospital, PO Box 792, Seven Hills, NSW 2147, Australia.

出版信息

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):63-72. doi: 10.1016/j.bbadis.2018.10.020. Epub 2018 Oct 22.

DOI:10.1016/j.bbadis.2018.10.020

PMID:30352258

Abstract

In just over a generation overweight and obesity has become a worldwide health concern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut microbiome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptin and adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.

摘要

在短短一代人的时间里，超重和肥胖已成为全球关注的健康问题。这对未来医疗保健成本和寿命的影响是相应的，而肥胖是糖尿病、肾脏和骨骼衰竭以及癌症的先兆。人们对肥胖在炎症性肠病 (IBD) 中的作用非常感兴趣，IBD 主要表现为克罗恩病 (CD) 和溃疡性结肠炎 (UC)。将 IBD 与西方饮食联系起来的研究结果存在差异。然而，精心设计的研究在人类中发现了基因多态性，在鼠模型中与 IBD 患者中观察到的炎症和肠道微生物组变化相平行。然而，一个不容忽视的领域是脂肪细胞功能的改变导致肥胖，特别是本文的重点，即脂联素和瘦素等脂肪细胞因子水平的失调。在此，我们介绍并讨论了西方饮食对患者和啮齿动物模型中 IBD 的已知影响，以及脂肪细胞因子如何影响 IBD 疾病过程。