Department of Analytical Chemistry, Jilin Institute of Chemical Technology, No. 45 Chengde Street, Jilin 132022, PR China.
Department of Analytical Chemistry, Jilin Institute of Chemical Technology, No. 45 Chengde Street, Jilin 132022, PR China.
J Chromatogr A. 2018 Dec 7;1579:1-8. doi: 10.1016/j.chroma.2018.10.019. Epub 2018 Oct 15.
In this study, a unique core-shell titanium-based metal-organic framework (MOF) functionalized magnetic microsphere was constructed and utilized as magnetic adsorbent for enrichment of five fluoroquinolones from water samples. The received magnetic MOF nanocomposite, denoted as FeO@Cys@MIL125-NH, showed strong magnetic responsiveness, and good hydrophilicity, as well as excellent affinity to the target analytes. Under optimal conditions, the developed magnetic solid-phase extraction (MSPE) method, combined with ultra-high performance liquid chromatography (UPLC), showed good linearity within the studied concentration range, and low limits of detection (0.05-0.2 μg L). The accuracy of the developed method was evaluated by measuring the extraction recovery of the spiked tap water and river water samples. The satisfactory recoveries of five fluoroquinolones were in the range of 83.8-109.4% with the RSDs lower than 8.9%. These results indicated that the as-prepared FeO-Cys@MIL125-NH is a promising magnetic adsorbent for efficient enrichment of fluoroquinolones from tap water and environmental water samples.
在这项研究中，构建了一种独特的核壳型钛基金属有机骨架（MOF）功能化磁性微球，并将其用作从水样中富集五种氟喹诺酮类药物的磁性吸附剂。所得到的磁性 MOF 纳米复合材料，记为 FeO@Cys@MIL125-NH，具有强磁响应性、良好的亲水性以及对目标分析物的优异亲和力。在最佳条件下，所开发的磁固相萃取（MSPE）方法与超高效液相色谱（UPLC）相结合，在所研究的浓度范围内表现出良好的线性关系，并且检测限低（0.05-0.2μg L）。通过测量加标自来水和河水样品的萃取回收率来评估该方法的准确性。五种氟喹诺酮类药物的回收率令人满意，在 83.8-109.4%范围内，相对标准偏差（RSD）低于 8.9%。这些结果表明，所制备的 FeO-Cys@MIL125-NH 是一种有前途的磁性吸附剂，可用于从自来水和环境水样中高效富集氟喹诺酮类药物。
