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[铜绿假单胞菌的抗生素耐药性:阿比让科科迪大学医院中心的一个事实与问题]

[Antibiotic resistance of Pseudomonas aeruginosa: a fact and a problem at the University Hospital Center of Cocody (Abidjan)].

作者信息

Aka J, Dosso M, Michel G

出版信息

Med Trop (Mars). 1987 Jan-Mar;47(1):53-9.

PMID:3035318
Abstract

The in vitro activity of 4 beta lactam compounds (carbenicillin, ampicillin, cefotaxim, azlocillin), 4 aminoglycosides (gentamicin, dibekacin, netilmicin, amikacin), chloramphénicol and tetracyclin chlorhydrate was studied on 30 strains of Pseudomonas aeruginosa. Amikacin is the most efficient with 97% of sensitive strains, then dibekacin (80%), azlocillin (76%) and carbenicillin (73%). Gentamicin and netilmicin are the less efficient with respectively 43% and 63% resistant strains. Chloramphenicol, ampicillin and cefotaxim have not any activity on these strains. This study reveals that 3% of the strains are polyresistant.

摘要

研究了4种β-内酰胺类化合物(羧苄青霉素、氨苄青霉素、头孢噻肟、阿洛西林)、4种氨基糖苷类抗生素(庆大霉素、地贝卡星、奈替米星、阿米卡星)、氯霉素和四环素盐酸盐对30株铜绿假单胞菌的体外活性。阿米卡星最有效,敏感菌株占97%,其次是地贝卡星(80%)、阿洛西林(76%)和羧苄青霉素(73%)。庆大霉素和奈替米星效果较差,耐药菌株分别占43%和63%。氯霉素、氨苄青霉素和头孢噻肟对这些菌株无活性。该研究表明3%的菌株具有多重耐药性。

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