Nitzan Y, Sharon R, Maayan M, Steuerman C
Isr J Med Sci. 1985 Oct;21(10):798-803.
Patients screened for antibiotic resistance at three different medical institutions yielded 1,597 isolates of Pseudomonas aeruginosa. Most of the isolates were sensitive to amikacin (92.8%), tobramycin (70.6%), gentamicin (59.1%) neomycin (89.4%), azlocillin (84.6%), mezlocillin (83.9%), piperacillin (85.7%), cefsulodin (83.8%) and colistin (98.5%); only 43.8% were sensitive to carbenicillin. In a rehabilitation hospital the frequency of isolates resistant to most of these antibiotics was twice as high than in the two other institutions. The frequency of phenotypes resistant to the combination of carbenicillin and gentamicin was twice as high in the rehabilitation hospital isolates (47.3%) than in the general hospital isolates (28.5%). The frequency of isolates resistant to the combination of aminoglycosides and the new beta-lactam antibiotics is relatively lower than in the former combinations. Serogroup 11 is predominant in the isolates from all three institutions (44%). In carbenicillin- and gentamicin-resistant isolates, 61% were of serogroup 11. On the other hand, in the carbenicillin- and gentamicin-sensitive isolates, serogroup 11 accounted for only 27.2%.
在三家不同医疗机构接受抗生素耐药性筛查的患者中，共分离出1597株铜绿假单胞菌。大多数分离株对阿米卡星（92.8%）、妥布霉素（70.6%）、庆大霉素（59.1%）、新霉素（89.4%）、阿洛西林（84.6%）、美洛西林（83.9%）、哌拉西林（85.7%）、头孢磺啶（83.8%）和黏菌素（98.5%）敏感；只有43.8%对羧苄西林敏感。在一家康复医院，对大多数这些抗生素耐药的分离株频率比另外两家机构高出两倍。康复医院分离株中对羧苄西林和庆大霉素联合耐药的表型频率（47.3%）是综合医院分离株（28.5%）的两倍。对氨基糖苷类和新型β-内酰胺类抗生素联合耐药的分离株频率相对低于前一种联合情况。血清群11在所有三家机构的分离株中占主导地位（44%）。在对羧苄西林和庆大霉素耐药的分离株中，61%属于血清群11。另一方面，在对羧苄西林和庆大霉素敏感的分离株中，血清群11仅占27.2%。
