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急性区域性隐匿性外层视网膜病变:光相干断层扫描血管造影是否有用?

Acute zonal occult outer retinopathy: Is optical coherence tomography angiography useful?

机构信息

Shri Bhagwan Mahavir Vitreoretinal Services, Chennai, Tamil Nadu, India.

Deparment of Uvea and Ocular Pathology, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

出版信息

Indian J Ophthalmol. 2018 Nov;66(11):1637-1639. doi: 10.4103/ijo.IJO_966_18.

DOI:10.4103/ijo.IJO_966_18
PMID:30355889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6213690/
Abstract

A 44-year-old female presented with central vision loss and photopsia in both eyes since 2 months. Multimodal imaging, field defects, electroretinogram abnormalities, and spectral domain optical coherence tomography changes were all suggestive of acute zonal occult outer retinopathy. En-face optical coherence tomography angiography (OCTA) images demonstrated hyper-reflective dots at the level of ellipsoid zone in both eyes in the presence of normal retinochoroidal vasculature. The patient was started on oral azathioprine and prednisolone. On two consecutive monthly follow-ups, en-face OCTA images demonstrated serial changes in the hyper-reflective dot morphology at ellipsoid zone level that have not been previously reported in the literature.

摘要

一位 44 岁女性因双眼中心视力丧失和光幻视就诊,病史已有 2 个月。多模态成像、视野缺损、视网膜电图异常和谱域光学相干断层扫描改变均提示急性区域性隐匿性外层视网膜病变。颜面光学相干断层扫描血管造影(OCTA)图像显示双眼在正常脉络膜视网膜血管的情况下,在椭圆体带水平呈现高反射点。患者开始口服硫唑嘌呤和泼尼松龙治疗。在连续两次每月随访中,颜面 OCTA 图像显示椭圆体带水平高反射点形态的连续变化,这在文献中尚未有报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/44d7ebdc01f6/IJO-66-1637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/cfc048a493bc/IJO-66-1637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/22b1b9db5a05/IJO-66-1637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/866fe95a4857/IJO-66-1637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/44d7ebdc01f6/IJO-66-1637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/cfc048a493bc/IJO-66-1637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/22b1b9db5a05/IJO-66-1637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/866fe95a4857/IJO-66-1637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7e/6213690/44d7ebdc01f6/IJO-66-1637-g004.jpg

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本文引用的文献

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Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy.急性区域性隐匿性外层视网膜病变中脉络膜厚度与视野损害的关系
J Ophthalmol. 2017;2017:2371032. doi: 10.1155/2017/2371032. Epub 2017 Jul 5.
2
OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy.光学相干断层扫描血管造影术对急性区域性隐匿性外层视网膜病变继发脉络膜新生血管的识别
Ophthalmic Surg Lasers Imaging Retina. 2016 Jan;47(1):73-5. doi: 10.3928/23258160-20151214-11.
3
Correlation between decreased choroidal blood flow velocity and the pathogenesis of acute zonal occult outer retinopathy.
光学相干断层扫描血管造影(OCTA)作为葡萄膜炎的一种新型诊断工具。
J Ophthalmic Inflamm Infect. 2019 May 28;9(1):10. doi: 10.1186/s12348-019-0176-9.
脉络膜血流速度降低与急性区域性隐匿性外层视网膜病变发病机制的相关性。
Clin Exp Ophthalmol. 2014 Mar;42(2):139-50. doi: 10.1111/ceo.12143. Epub 2013 Jul 11.
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Acute zonal occult outer retinopathy.急性区域性隐匿性外层视网膜病变。
Surv Ophthalmol. 2011 Jan-Feb;56(1):23-35. doi: 10.1016/j.survophthal.2010.07.004. Epub 2010 Nov 5.
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Are acute zonal occult outer retinopathy and the white spot syndromes (AZOOR complex) specific autoimmune diseases?急性区域性隐匿性外层视网膜病变和白点综合征(AZOOR 综合征)是特异性自身免疫性疾病吗?
Am J Ophthalmol. 2003 Mar;135(3):380-1. doi: 10.1016/s0002-9394(03)00030-8.
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White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease.视网膜白斑综合征:基于自身免疫/炎症性疾病共同遗传假说的一种假设。
Am J Ophthalmol. 2003 Mar;135(3):376-9. doi: 10.1016/s0002-9394(02)02088-3.
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Acute zonal occult outer retinopathy. Donders Lecture: The Netherlands Ophthalmological Society, Maastricht, Holland, June 19, 1992.急性区域性隐匿性外层视网膜病变。唐德斯讲座:荷兰眼科协会,荷兰马斯特里赫特,1992年6月19日。
J Clin Neuroophthalmol. 1993 Jun;13(2):79-97.