Hashimoto Yuki, Saito Wataru, Saito Michiyuki, Hasegawa Yuka, Takita Akari, Mori Shohei, Noda Kousuke, Ishida Susumu
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kaimeido Eye and Dental Clinic, Sapporo, Japan.
J Ophthalmol. 2017;2017:2371032. doi: 10.1155/2017/2371032. Epub 2017 Jul 5.
To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR).
This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced depth imaging optical coherence tomography, choroidal thicknesses at the subfovea and at nasal and temporal sites 1000 m away from the fovea were manually measured at baseline and 3 and 6 months thereafter. Changes in the choroidal thicknesses and the average threshold at the affected area on Humphrey perimetry were compared during the 6-month follow-up.
In AZOOR eyes, the average threshold at the affected area significantly increased over time, while outer retinal structure ameliorated. The mean choroidal thicknesses at all the sites measured significantly decreased at 3 and 6 months compared with baseline values in AZOOR eyes, but not in fellow eyes. There was an inverse correlation between the changing rates of the average threshold and the subfoveal choroidal thickness at 6 months from baseline.
The current data suggest that choroidal thickness at AZOOR-affected area significantly decreased with regression of AZOOR and this anatomical change correlated with the functional recovery.
评估急性区域性隐匿性外层视网膜病变（AZOOR）患者患眼病变区域脉络膜厚度的连续变化。
该回顾性观察性病例系列纳入了10例黄斑区受损的AZOOR患者的14只患眼和6只对侧未患眼。使用增强深度成像光学相干断层扫描技术，在基线期以及之后3个月和6个月时，手动测量黄斑中心凹下以及距中心凹1000μm处鼻侧和颞侧部位的脉络膜厚度。在6个月的随访期间，比较脉络膜厚度的变化以及Humphrey视野计上患眼病变区域的平均阈值。
在AZOOR患眼中，患眼病变区域的平均阈值随时间显著升高，而外层视网膜结构有所改善。与基线值相比，AZOOR患眼中所有测量部位的平均脉络膜厚度在3个月和6个月时均显著降低，但对侧未患眼则无此变化。从基线起6个月时，平均阈值变化率与黄斑中心凹下脉络膜厚度变化率之间呈负相关。
目前的数据表明，随着AZOOR病情的消退，AZOOR患眼病变区域的脉络膜厚度显著降低，且这种解剖学变化与功能恢复相关。
