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微重力与微重力和辐射：研究神经内分泌免疫系统的变化及中药配方的拮抗作用。

Microgravity versus Microgravity and Irradiation: Investigating the Change of Neuroendocrine-Immune System and the Antagonistic Effect of Traditional Chinese Medicine Formula.

机构信息

School of Traditional Chinese Medicine, Bejing University of Chinese Medicine, Beijing 100029, China.

School of Traditional Chinese Medicine, Liaoning University of Chinese Medicine, Shenyang, Liaoning 110847, China.

出版信息

Biomed Res Int. 2020 May 26;2020:2641324. doi: 10.1155/2020/2641324. eCollection 2020.

DOI:10.1155/2020/2641324
PMID:32566675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7273471/
Abstract

During spaceflight, the homeostasis of the living body is threatened with cosmic environment including microgravity and irradiation. Traditional Chinese medicine could ameliorate the internal imbalance during spaceflight, but its mechanism is still unclear. In this article, we compared the difference of neuroendocrine-immune balance between simulated microgravity (S) and simulated microgravity and irradiation (SAI) environment. We also observed the antagonistic effect of SAI using a traditional Chinese medicine formula (TCMF). Wistar rats were, respectively, exposed under S using tail suspending and SAI using tail suspending and Co-gama irradiation exposure. The SAI rats were intervened with TCMF. The changes of hypothalamic-pituitary-adrenal (HPA) axis, splenic T-cell, celiac macrophages, and related cytokines were observed after 21 days. Compared with the normal group, the hyperfunction of HPA axis and celiac macrophages, as well as the hypofunction of splenic T-cells, was observed in both the S and SAI group. Compared with the S group, the levels of plasmatic corticotropin-releasing hormone (CRH), macrophage activity, and serous interleukin-6 (IL-6) in the SAI group were significantly reduced. The dysfunctional targets were mostly reversed in the TCMF group. Both S and SAI could lead to NEI imbalance. Irradiation could aggravate the negative feedback inhibition of HPA axis and macrophages caused by S. TCMF could ameliorate the NEI dysfunction caused by SAI.

摘要

在航天飞行中，生物体的内稳态受到微重力和辐射等宇宙环境的威胁。中药可以改善航天飞行过程中的内部失衡，但作用机制尚不清楚。在本文中，我们比较了模拟微重力（S）和模拟微重力加辐射（SAI）环境下神经内分泌免疫平衡的差异。我们还观察了一种中药配方（TCMF）对 SAI 的拮抗作用。Wistar 大鼠分别采用尾部悬吊法暴露于 S 中，采用尾部悬吊和 Co-gama 照射法暴露于 SAI 中。SAI 大鼠接受 TCMF 干预。21 天后，观察下丘脑-垂体-肾上腺（HPA）轴、脾 T 细胞、腹腔巨噬细胞和相关细胞因子的变化。与正常组相比，S 和 SAI 组均出现 HPA 轴和腹腔巨噬细胞功能亢进，脾 T 细胞功能减退。与 S 组相比，SAI 组血浆促肾上腺皮质激素释放激素（CRH）、巨噬细胞活性和血清白细胞介素 6（IL-6）水平明显降低。TCMF 组的功能障碍靶点大多得到逆转。S 和 SAI 均可导致 NEI 失衡。辐射会加重 S 引起的 HPA 轴和巨噬细胞负反馈抑制。TCMF 可改善 SAI 引起的 NEI 功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/994ba1c143b6/BMRI2020-2641324.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/f016c5635359/BMRI2020-2641324.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/954e7eb895c1/BMRI2020-2641324.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/d8807e6c36bd/BMRI2020-2641324.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/cd78e2371601/BMRI2020-2641324.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/ba8da15a7899/BMRI2020-2641324.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/994ba1c143b6/BMRI2020-2641324.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/f016c5635359/BMRI2020-2641324.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/954e7eb895c1/BMRI2020-2641324.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/d8807e6c36bd/BMRI2020-2641324.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/cd78e2371601/BMRI2020-2641324.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/ba8da15a7899/BMRI2020-2641324.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f7/7273471/994ba1c143b6/BMRI2020-2641324.006.jpg

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