Grasel Signe, Greters Mario, Goffi-Gomez Maria Valeria Schimidt, Bittar Roseli, Weber Raimar, Oiticica Jeanne, Bento Ricardo Ferreira
Department of Otolaryngology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Department of Otolaryngology, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
Int Arch Otorhinolaryngol. 2018 Oct;22(4):408-414. doi: 10.1055/s-0037-1613687. Epub 2018 Apr 24.
The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal hearing subjects matched for age and educational level. In this prospective cohort study, auditory cortical responses were recorded from 26 post-lingual deaf adult cochlear implant users (19 with good and 7 with poor speech recognition scores) and 26 control subjects. There was a significant difference in the P3 latency between cochlear implant users with poor speech recognition scores (G-) and their control group (CG) ( = 0.04), and between G- and cochlear implant users with good speech discrimination (G+) ( = 0.01). We found no significant difference in the P3 latency between the CG and G+. In this study, all G- patients had deafness due to meningitis, which suggests that higher auditory function was impaired too. Post-lingual deaf adult cochlear implant users in the G- group had prolonged P3 latencies as compared with the CG and the cochlear implant users in the G+ group. The amplitudes were similar between patients and controls. All G- subjects were deaf due to meningitis. These findings suggest that meningitis may have deleterious effects not only on the peripheral auditory system but on the central auditory processing as well.
当受试者正确识别、评估和处理两种不同的听觉刺激时，记录P3认知诱发电位。为了评估26名语后聋人工耳蜗使用者的P3诱发电位的潜伏期和波幅，这些使用者的言语识别分数有高有低，并与年龄和教育水平相匹配的正常听力受试者进行比较。在这项前瞻性队列研究中，记录了26名语后聋成年人工耳蜗使用者（19名言语识别分数高，7名言语识别分数低）和26名对照受试者的听觉皮层反应。言语识别分数低的人工耳蜗使用者（G-）与其对照组（CG）之间的P3潜伏期存在显著差异（P = 0.04），G-与言语辨别能力好的人工耳蜗使用者（G+）之间也存在显著差异（P = 0.01）。我们发现CG和G+之间的P3潜伏期没有显著差异。在本研究中，所有G-患者均因脑膜炎导致耳聋，这表明更高层次的听觉功能也受到了损害。与CG组和G+组的人工耳蜗使用者相比，G-组的语后聋成年人工耳蜗使用者的P3潜伏期延长。患者和对照组之间的波幅相似。所有G-受试者均因脑膜炎而失聪。这些发现表明，脑膜炎不仅可能对周围听觉系统有有害影响，而且对中枢听觉处理也有影响。
