[二甲基亚砜对大鼠的抗应激作用]
[Antistress effect of dimethyl sulfoxide in the rat].
作者信息
Levshina I P, Guliaeva N V, Obidin A B, Kurochkina E V
出版信息
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Mar-Apr;37(2):350-5.
Administration of scavenger of hydroxyl radicals--dimethylsulfoxide (1 g/kg intraperitoneally, daily for 3 weeks) did not lead to any significant changes in animals behaviour in the open field and in visceral functions (arterial pressure, respiratory rate, heart rate) but prevented shifts of these characteristics caused by chronic 3-week emotional-pain stress. In rats injected with dimethylsulfoxide, an increase was observed of superoxide dismutase activity in the brain and blood serum. Molecular mechanisms are discussed of antistress action of dimethylsulfoxide (scavenge of hydroxyl radicals, activation of superoxide dismutase) and possible role of hydroxyl radicals in realization of damaging action of stress on the organism.
给予羟基自由基清除剂——二甲基亚砜（腹腔注射1克/千克，每日一次，共3周），并未导致动物在旷场试验中的行为以及内脏功能（动脉血压、呼吸频率、心率）出现任何显著变化，但可防止因为期3周的慢性情绪性疼痛应激所引起的这些特征的改变。在注射了二甲基亚砜的大鼠中，观察到大脑和血清中超氧化物歧化酶活性增加。讨论了二甲基亚砜抗应激作用的分子机制（清除羟基自由基、激活超氧化物歧化酶）以及羟基自由基在应激对机体造成损伤作用的实现过程中可能发挥的作用。
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