Guliaeva N V, Levshina I P
Biull Eksp Biol Med. 1988 Aug;106(8):153-6.
During the phase of long-lasting adaptation to chronic emotional painful stress three stages have been distinguished on the basis of physiological and neurobiochemical data. The first stage (1 week of stress)--transition from urgent to long-lasting adaptation--corresponds to labilization of vegetative indices, predominance of fear reactions and suppression of research behaviour in rats, inhibition of lipid peroxidation, activation of superoxide scavenging activity, decrease in cholesterol content in brain lipids. The second stage (2 weeks of stress)--long-lasting adaptation--is characterized by normalization of the behaviour, stabilization of high blood pressure, maximum brain antiradical activity and low level of lipid peroxidation. The third stage (3 weeks of stress)--transition from long-lasting adaptation to exhaustion--is characterized by blood pressure lowering, disturbed regulation of vegetative functions, behavioural hyperactivity in the open field, increased lipid peroxidation and decreased phospholipid content.
在对慢性情绪性疼痛应激进行长期适应的阶段，根据生理和神经生化数据区分出了三个阶段。第一阶段（应激1周）——从紧急适应向长期适应的转变——对应于植物性指标的不稳定、大鼠恐惧反应占主导以及探究行为受到抑制、脂质过氧化受到抑制、超氧化物清除活性被激活、脑脂质中胆固醇含量降低。第二阶段（应激2周）——长期适应——的特征是行为正常化、高血压稳定、大脑抗自由基活性达到最大值以及脂质过氧化水平较低。第三阶段（应激3周）——从长期适应向衰竭的转变——的特征是血压降低、植物性功能调节紊乱、旷场试验中行为活动亢进、脂质过氧化增加以及磷脂含量降低。
