Nedz'ved' G K, Levin V I, Semenov G V, Shkol'nikov P L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(4):503-5.
Examinations of the HLA antigens (A and B loci) distribution in patients with neurologic manifestations of lumbar osteochondrosis (NMLO) has revealed a statistically more rare incidence of A11 antigens and a more frequent one, of B7 and B18 ones. A different distribution of the antigens in cases with the major clinical forms of lumbar osteochondrosis was noted. Patients with discogenic lumbosacral radiculitis differed from normal subjects by the same antigens as all NMLO patients. For patients with lumbar ischialgia increased concentrations of B7 and B18 antigens were characteristic, whereas in radicular ischialgias A11 and B15 antigens were less incident and B40 one, more incident. The findings confirm the polygenic nature of hereditary predisposition to NMLO.
对腰椎骨软骨病神经症状（NMLO）患者的人类白细胞抗原（A和B位点）分布进行检查发现，A11抗原的发生率在统计学上更为罕见，而B7和B18抗原的发生率则更为频繁。在腰椎骨软骨病的主要临床形式病例中，注意到抗原的分布有所不同。椎间盘源性腰骶神经根炎患者与所有NMLO患者一样，在相同抗原方面与正常受试者存在差异。对于腰椎坐骨神经痛患者，B7和B18抗原浓度升高是其特征，而在神经根性坐骨神经痛中，A11和B15抗原发生率较低，B40抗原发生率较高。这些发现证实了NMLO遗传易感性的多基因性质。
