Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.
作者信息
Maliken Bryan D, Molkentin Jeffery D
机构信息
University of Cincinnati and Cincinnati Children's Hospital Medical Center, OH (B.D.M., J.D.M.).
Howard Hughes Medical Institute, Cincinnati Children's Hospital Research Foundation, OH (J.D.M.).
出版信息
Circulation. 2018 Aug 21;138(8):806-808. doi: 10.1161/CIRCULATIONAHA.118.035186.
Abstract
摘要
相似文献
1
Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.成年哺乳动物心脏缺乏内源性再生干细胞的确凿证据。
Circulation. 2018 Aug 21;138(8):806-808. doi: 10.1161/CIRCULATIONAHA.118.035186.
2
Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases.双重组酶对非心肌细胞群体的遗传谱系追踪。
Circulation. 2018 Aug 21;138(8):793-805. doi: 10.1161/CIRCULATIONAHA.118.034250.
3
Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision.基于双重组酶的遗传谱系示踪技术，可提高干细胞研究的精确性。
Sci China Life Sci. 2021 Dec;64(12):2060-2072. doi: 10.1007/s11427-020-1889-9. Epub 2021 Apr 9.
4
Enhancing the precision of genetic lineage tracing using dual recombinases.使用双重组酶提高遗传谱系追踪的精度。
Nat Med. 2017 Dec;23(12):1488-1498. doi: 10.1038/nm.4437. Epub 2017 Nov 13.
5
Triple-cell lineage tracing by a dual reporter on a single allele.通过单一位点上的双报告基因对三细胞谱系进行示踪。
J Biol Chem. 2020 Jan 17;295(3):690-700. doi: 10.1074/jbc.RA119.011349. Epub 2019 Nov 26.
6
Switching on lineage tracers using site-specific recombination.利用位点特异性重组开启谱系示踪剂。
Methods Mol Biol. 2002;185:309-34. doi: 10.1385/1-59259-241-4:309.
7
Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes.利用羟喜树碱脂质体进行克隆谱系关系的遗传剖析。
Nat Commun. 2018 Jul 30;9(1):2971. doi: 10.1038/s41467-018-05436-6.
8
Developmental origin and lineage plasticity of endogenous cardiac stem cells.内源性心脏干细胞的发育起源与谱系可塑性
Development. 2016 Apr 15;143(8):1242-58. doi: 10.1242/dev.111591.
9
Perfect duet: Dual recombinases improve genetic resolution.完美二重奏：双重组酶提高遗传分辨率。
Cell Prolif. 2023 May;56(5):e13446. doi: 10.1111/cpr.13446. Epub 2023 Apr 14.
10
Conditional gene mutagenesis in B-lineage cells.B 淋巴细胞系细胞中的条件性基因诱变
Methods Mol Biol. 2004;271:91-109. doi: 10.1385/1-59259-796-3:091.
引用本文的文献
1
Differential regulation during development, aging, and disease implies heart cell specific functions of the Mediator Complex.在发育、衰老和疾病过程中的差异调节意味着中介复合体具有心脏细胞特异性功能。
J Mol Cell Cardiol Plus. 2025 May 22;12:100456. doi: 10.1016/j.jmccpl.2025.100456. eCollection 2025 Jun.
2
Healing the Ischaemic Heart: A Critical Review of Stem Cell Therapies.治疗缺血性心脏病：干细胞疗法的批判性综述
Rev Cardiovasc Med. 2023 Apr 19;24(4):122. doi: 10.31083/j.rcm2404122. eCollection 2023 Apr.
3
The role of cardiac microenvironment in cardiovascular diseases: implications for therapy.心脏微环境在心血管疾病中的作用：对治疗的启示。
Hum Cell. 2024 May;37(3):607-624. doi: 10.1007/s13577-024-01052-3. Epub 2024 Mar 18.
4
Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.从小鼠指尖和心脏看动物王国中的再生损失。
Dev Biol. 2024 Mar;507:44-63. doi: 10.1016/j.ydbio.2023.12.008. Epub 2023 Dec 24.
5
Keratose Hydrogel Drives Differentiation of Cardiac Vascular Smooth Muscle Progenitor Cells: Implications in Ischemic Treatment.角质化水凝胶驱动心脏血管平滑肌祖细胞分化：对缺血治疗的意义。
Stem Cell Rev Rep. 2023 Oct;19(7):2341-2360. doi: 10.1007/s12015-023-10574-6. Epub 2023 Jul 1.
6
Wnt Signaling in Heart Development and Regeneration.Wnt 信号在心脏发育和再生中的作用。
Curr Cardiol Rep. 2022 Oct;24(10):1425-1438. doi: 10.1007/s11886-022-01756-8. Epub 2022 Aug 4.
7
The G Protein-Coupled Receptor Latrophilin-2, A Marker for Heart Development, Induces Myocardial Repair After Infarction.G 蛋白偶联受体 latrophilin-2 是心脏发育的标志物，可诱导梗死心肌修复。
Stem Cells Transl Med. 2022 Mar 31;11(3):332-342. doi: 10.1093/stcltm/szab015.
8
Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity.生长分化因子 11 通过增强线粒体生物发生和端粒酶活性来减轻心肌缺血再灌注损伤。
Cell Death Dis. 2021 Jul 2;12(7):665. doi: 10.1038/s41419-021-03954-8.
9
Control of cardiomyocyte differentiation timing by intercellular signaling pathways.细胞间信号通路对心肌细胞分化时机的控制。
Semin Cell Dev Biol. 2021 Oct;118:94-106. doi: 10.1016/j.semcdb.2021.06.002. Epub 2021 Jun 16.
10
Setd4 controlled quiescent c-Kit cells contribute to cardiac neovascularization of capillaries beyond activation.Setd4 控制静止的 c-Kit 细胞有助于毛细血管的心脏新生血管生成，超出激活状态。
Sci Rep. 2021 Jun 2;11(1):11603. doi: 10.1038/s41598-021-91105-6.
本文引用的文献
1
Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases.双重组酶对非心肌细胞群体的遗传谱系追踪。
Circulation. 2018 Aug 21;138(8):793-805. doi: 10.1161/CIRCULATIONAHA.118.034250.
2
Kit knock-in mice fail to fate-map cardiac stem cells.试剂盒敲入小鼠无法对心脏干细胞进行命运图谱分析。
Nature. 2018 Mar 21;555(7697):E1-E5. doi: 10.1038/nature25771.
3
Enhancing the precision of genetic lineage tracing using dual recombinases.使用双重组酶提高遗传谱系追踪的精度。
Nat Med. 2017 Dec;23(12):1488-1498. doi: 10.1038/nm.4437. Epub 2017 Nov 13.
4
Cardiomyocyte Regeneration: A Consensus Statement.心肌细胞再生：一份共识声明。
Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6.
5
The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away.心脏再生中难以捉摸的祖细胞：渐行渐远。
Circ Res. 2017 Jan 20;120(2):400-406. doi: 10.1161/CIRCRESAHA.116.309710.
6
Stem cell therapy for chronic ischaemic heart disease and congestive heart failure.用于慢性缺血性心脏病和充血性心力衰竭的干细胞疗法。
Cochrane Database Syst Rev. 2016 Dec 24;12(12):CD007888. doi: 10.1002/14651858.CD007888.pub3.
7
Clarifying Stem-Cell Therapy's Benefits and Risks.阐明干细胞疗法的益处与风险。
N Engl J Med. 2017 Mar 16;376(11):1007-1009. doi: 10.1056/NEJMp1613723. Epub 2016 Nov 30.
8
Dating the Heart: Exploring Cardiomyocyte Renewal in Humans.心脏的年代测定：探索人类心肌细胞更新
Physiology (Bethesda). 2017 Jan;32(1):33-41. doi: 10.1152/physiol.00015.2016.
9
Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.遗传谱系追踪鉴定出原位表达Kit的心肌细胞。
Cell Res. 2016 Jan;26(1):119-30. doi: 10.1038/cr.2015.143. Epub 2015 Dec 4.
10
Resident c-kit(+) cells in the heart are not cardiac stem cells.心脏中的常驻c-kit(+)细胞并非心脏干细胞。
Nat Commun. 2015 Oct 30;6:8701. doi: 10.1038/ncomms9701.
Zotero 插件